CRC 1450 - C05: The role of IL24 in development and resolution of acute kidney injury
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 31/12/2024 | 1st Funding period
Description
Acute kidney injury (AKI) is characterised by impaired perfusion, a metabolic shift towards anaerobic glucose consumption and the secretion of pro-inflammatory mediators. We hypothesize that interleukin 24, which we recently identified in kidneys with AKI, is a key mediator in AKI. This leads us to investigate the influence of interleukin 24 on the functional, metabolic and cellular response of kidney cells and leukocytes during all stages of AKI. We will use a multiscale imaging approach with special emphasis on the development and application of novel magnetic resonance imaging (MRI) techniques, such as Chemical Exchange Saturation Transfer (CEST) MRI.
Keywords: Acute kidney injury; Radiology; Nuclear Medicine; Radiotherapy; Radiobiology
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-C/C05.php
Funding identifier: SFB 1450/1, C05
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Hörr, Verena | Clinic of Radiology |
| Reuter, Stefan Johannes | Nephrological Institute |
Applicants from the University of Münster
| Hörr, Verena | Clinic of Radiology |
| Reuter, Stefan Johannes | Nephrological Institute |