CRC 1450 - A06: Improving intravital microscopy of inflammatory cell response by active motion compensation using controlled adaptive optics
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 31/12/2024 | 1st Funding period
Description
We will advance multiphoton fluorescence microscopy by developing a novel optical module comprised of a high-speed deformable mirror that will actively compensate tissue motion during intravital imaging, for instance due to heart beat (8 Hz), breathing (3 Hz, in mm-range) or peristaltic movement of the gut in mice. To control this module in real-time, we will develop mathematical methods that track and predict tissue deformation. This will allow imaging of inflammatory processes at cellular resolution without mechanical tissue fixation.
Keywords: intravital microscopy; Biophysics; analysis; numerics; Photonics
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-A/A06.php
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/452338116
Funding identifier: SFB 1450/1, A06 | DFG project number: 431460824
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Wirth, Benedikt |
Applicants from the University of Münster
| Wirth, Benedikt |
Project partners outside the University of Münster
- Bielefeld UniversityGermany
Projects of the following funding period
Duration: 01/01/2025 - 31/12/2028 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/01/2021 - 31/12/2024 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |