CRC 1450 - A04: Metabolic targeting of bacteria through complex carbohydrates
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 31/12/2024 | 1st Funding period
Description
We aim to develop reliable diagnostic tools that enable the differentiation between sterile inflammation and bacterial infection. Therefore, we will design radiolabelled specific imaging probes based on oligosaccharides which are selectively taken up by bacteria. These tracers will be tested in vitro as well as in vivo with gram-positive and gram-negative bacterial strains providing us information on the possible applications in clinical practice. In mouse models we will follow bacterial infection non-invasively over time and analyse the interaction of bacteria with immune cells using novel tracers developed in this and other projects in this CRC.
Keywords: Complex carbohydrates; Radiology; Nuclear Medicine; Radiotherapy; Radiobiology
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-A/A04.php
Funding identifier: SFB 1450/1, A04
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Faust, Andreas | European Institute of Molecular Imaging (EIMI) |
| Gilmour, Ryan | Professur für Organische Chemie / Chemische Biologie (Prof. Gilmour) |
| Niemann, Silke | Institute of Medical Microbiology |
Applicants from the University of Münster
| Faust, Andreas | European Institute of Molecular Imaging (EIMI) |
| Gilmour, Ryan | Professur für Organische Chemie / Chemische Biologie (Prof. Gilmour) |
| Niemann, Silke | Institute of Medical Microbiology |