CRC 1450 - A03: Targeting of S100A8/A9 for imaging of inflammatory disorders
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2021 - 31/12/2024 | 1st Funding period
Description
Activated monocytes and granulocytes are key to inflammatory diseases and release the alarmin S100A8/A9 in high concentrations, triggering sterile as well as infectious inflammatory processes via TLR-4. In the proposed project we will establish a specific S100A8/A9 tracer combining X-ray structure analysis and chemical synthesis. The tracer core will be linked to different labels suited for PET, SPECT, fluorescent or photoacoustic imaging techniques. In summary, we will create a new toolset to monitor the onset of inflammatory responses, the spatio-temporal location and resolution of inflammation in the context of the whole organism.
Keywords: Radiology; Nuclear Medicine; Radiotherapy; Radiobiology; Microbiology
Website of the project: https://www.uni-muenster.de/CRC-inSight/research/area-A/A03.php
Funding identifier: SFB 1450/1, A03
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Faust, Andreas | European Institute of Molecular Imaging (EIMI) |
Applicants from the University of Münster
| Faust, Andreas | European Institute of Molecular Imaging (EIMI) |
Project partners outside the University of Münster
- University of HohenheimGermany