CRC 1009 B02 - The role of MAPK pathways in influenza virus replication and bacterial super-infection
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/07/2020 - 30/06/2024 | 3rd Funding period
Description
Influenza viruses are barrier breaking pathogens that exploit cellular pathways to promote their replication. We have identified the Raf/MEK/ERK MAPK pathway to play a crucial role in virus replication and showed that this dependency could be used for a novel anti-influenza approach using MEK inhibitors. In the new funding period, we will not only further study the role of the pathway in ERK-mediated vRNP nuclear export but also explore a newly identified contribution of immunomodulatory activity of MEK inhibitors to prevent virus and even super-infecting bacteria from breaking the immune barrier against infections.
Keywords: Molecular virology; Influenza
Website of the project: https://www.medizin.uni-muenster.de/sfb-1009/projekte/projektbereich-b/b-02.html
Funding identifier: SFB 1009/3, B02
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Börgeling, Yvonne | Institute of Molecular Virology |
| Ludwig, Stephan | Institute of Molecular Virology |
Applicants from the University of Münster
| Börgeling, Yvonne | Institute of Molecular Virology |
| Ludwig, Stephan | Institute of Molecular Virology |