CRC 1009 - B02: The role of MAPK pathways in influenza virus replication and bacterial super-infection

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/07/2020 - 30/06/2024 | 3rd Funding period

Description

Influenza viruses are barrier breaking pathogens that exploit cellular pathways to promote their replication. We have identified the Raf/MEK/ERK MAPK pathway to play a crucial role in virus replication and showed that this dependency could be used for a novel anti-influenza approach using MEK inhibitors. In the new funding period, we will not only further study the role of the pathway in ERK-mediated vRNP nuclear export but also explore a newly identified contribution of immunomodulatory activity of MEK inhibitors to prevent virus and even super-infecting bacteria from breaking the immune barrier against infections.

Keywords: Molecular virology; Influenza

Website of the project: https://www.medizin.uni-muenster.de/sfb-1009/projekte/projektbereich-b/b-02.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/222660511

Funding identifier: SFB 1009/3, B02 | DFG project number: 194468054

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Börgeling, Yvonne	Institute of Virology
Ludwig, Stephan	Institute of Virology

Applicants from the University of Münster

Börgeling, Yvonne	Institute of Virology
Ludwig, Stephan	Institute of Virology

Projects of the previous funding period

CRC 1009 B02 - The role of MAPK in influenza virus (IV) replication and bacterial super-infection

Duration: 01/07/2016 - 30/06/2020 | 2nd Funding period

Funded by: DFG - Collaborative Research Centre

Type of project: Subproject in DFG-joint project hosted at University of Münster

Related main project

CRC 1009 - Breaking Barriers - Immune Cells and Pathogens at Cell/Matrix Barriers

Duration: 01/07/2020 - 30/06/2024 | 3rd Funding period