CRC 1009 - A05: The role of intracellular calcium regulators in integrin activation and leukocyte recruitment

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/07/2020 - 30/06/2024 | 3rd Funding period

Description

During infections, leukocytes are rapidly recruited into inflamed tissues in a coordinated sequence of events that is needed for an adequate immune response. STIM calcium sensing proteins and ORAI-calcium channels are involved in store-operated calcium entry (SOCE) regulation in immune cells. Preliminary data indicate that STIM1 and ORAI1 are required for chemokine-induced integrin activation and neutrophil arrest. Here, we will address the following questions: 1) What is the interconnection between calcium-concentration regulating proteins and GTPases in neutrophils? 2) Which role do STIM and ORAI play during the regulation of integrin activity and 3) for the different steps of neutrophil recruitment?

Keywords: Immunology; anaesthesiology; Leukocyte biology

Website of the project: https://www.medizin.uni-muenster.de/sfb-1009/projekte/projektbereich-a/a-05.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/222656632

Funding identifier: SFB 1009/3, A05 | DFG project number: 194468054

Funder / funding scheme: