CRC TRR 156: The skin as sensor and effector orchestrating local and systemic immunity - C05: Scleroderma: role of macrophages and dendritic cells in tissue fibrosis
Basic data for this project
Type of project: Subproject in DFG-joint project hosted outside University of Münster
Duration at the University of Münster: since 01/01/2015 | 2nd Funding period
Description
The function of monocyte/macrophage differentiation and of dendritic cells in the pathogenesis of scleroderma (Scl), the skin manifestation of systemic sclerosis with extensive fibrosis, is not clear. We will alter the frequency, polarization and migration of myeloid/dendritic cells to test Scl development and the underlying immune mechanisms in chemically induced and spontaneous models of the disease. In addition, we will compare these data with that of monocytes/myeloid cells in the blood and the skin of patients suffering from systemic sclerosis to identify key (innate) cellular myeloid drivers and dominant molecular mechanisms of Scl.
Keywords: Dermatology; Rheumatology
Website of the project: https://www.klinikum.uni-heidelbehttps://www.klinikum.uni-heidelberg.de/sfbs/sfb-trr156/research/2-funding-period/research-area-c-skin-and-systemic-immunityrg.de/sfbs/sfb-trr156/research/
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Raker, Verena | Clinic for Dermatology |
| Steinbrink, Kerstin | Clinic for Dermatology |
Applicants from the University of Münster
| Steinbrink, Kerstin | Clinic for Dermatology |
Project partners outside the University of Münster
- University Medical Center of the Johannes Gutenberg University MainzGermany
Coordinating organisations outside the University of Münster
- Heidelberg UniversityGermany