CRC 863 - B09: Multiplexing FRET-based Tension Sensors to Reveal Cell Adhesion Forces during Collective Cell Migration
Basic data for this project
Type of project: Subproject in DFG-joint project hosted outside University of Münster
Duration at the University of Münster: 01/01/2019 - 31/12/2021 | 3rd Funding period
Description
In this project, we will apply a set of single-molecule calibrated tension sensor modules, which were developed and calibrated in the previous funding periods, to generate Förster resonance energy transfer (FRET)-based probes that report piconewton-scale forces across central components of integrin- and cadherin based adhesion structures. By combining these tension sensors with a recently established multiplexing approach, we will simultaneously investigate the molecular mechanics of cell-matrix and cell-cell adhesion during collective cell migration.
Keywords: Kraftsensoren; Zelladhäsionskräften; Zellwanderung
Website of the project: http://www.sfb863.de
Funding identifier: SFB 863/3
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Grashoff, Carsten | Professorship for quantitative cell biology |
Applicants from the University of Münster
| Grashoff, Carsten | Professorship for quantitative cell biology |
Project partners outside the University of Münster
- Technische Universität München (TUM)Germany
Coordinating organisations outside the University of Münster
- Technische Universität München (TUM)Germany