Design, synthesis and photophysics of metal-doped nucleic acids

Basic data for this project

Type of project: Individual project

Duration at the University of Münster: 01/04/2019 - 31/03/2022 | 1st Funding period

Description

In this project, nucleic acids with metal-based luminescence will be synthesized and characterized. In doing so, their photofunctionality will be investigated, opening up the opportunity for subsequent potential applications in biomedicine and functional microscopy. Towards this end, ligand-based nucleoside analogs will be synthesized, reacted with suitable transition metal complexes and subsequently incorporated into oligonucleotides by using automated solid phase synthesis. In addition, proximally (via the coordination plane) and distally (via an ancillary ligand) intercalating metal complexes will be synthesized and investigated. The doped nucleic acids obtained via these three strategies are ideally suited for an investigation of fundamental photophysical properties of polynuclear luminescent metal complexes.

Keywords: Photophysik; Nukleinsäure; Chemie

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/417637295

Funding identifier: MU 1750/5-1; STR 1186/7-1 | DFG project number: 417637295

Funder / funding scheme:

DFG - Individual Grants Programme

Project management at the University of Münster

Müller, Jens	Professorship of Inorganic Chemistry (Prof. Müller)
Strassert, Cristian	Professoship for Coordination Chemistry and Functional Imaging

Applicants from the University of Münster

Müller, Jens	Professorship of Inorganic Chemistry (Prof. Müller)
Strassert, Cristian	Professoship for Coordination Chemistry and Functional Imaging

Research associates from the University of Münster

Boisten, Felix

Professorship of Inorganic Chemistry (Prof. Müller)

Publications of the University of Münster resulting from the project

Monoanionic C^N^N Luminophores and Monodentate C-Donor Co-Ligands for Phosphorescent Pt(II) Complexes: A Case Study Involving Their Photophysics and Cytotoxicity Maisuls, I.; Boisten, F.; Hebenbrock, M.; Alfke, J.; Schürmann, L.; Jasper-Peter, B.; Hepp, A.; Esselen, M.; Müller, J.; Strassert, C. A. (2022) In: Inorganic Chemistry, 61(24), 9195-9204. doi:10.1021/acs.inorgchem.2c00753 Research article (journal) \| Peer reviewed \| Published
Site-specific covalent metalation of DNA oligonucleotides with phosphorescent platinum(II) complexes Boisten, F; Maisuls, I; Schäfer, T; Strassert, CA; Müller, J (2023) In: Chemical science, 14, 2399-2403. doi:10.1039/D2SC05916A Research article (journal) \| Peer reviewed \| Published
Tetracationic phosphonium-bridged ladder stilbenes: Redox states and electronic properties of highly charged P-heteropolycyclic materials Senn, S; Konrad, N; Müller, J; Ballmann, J; Gade, LH (2026) In: Chemical communications, 62, 6391-6395. doi:10.1039/D6CC00544F Research article (journal) \| Peer reviewed \| Published

Doctorates resulting from the project

Kovalent mit DNA verknüpfte lumineszente Platin(II)-Komplexe
Candidate: Boisten, Felix | Supervisors: Müller, Jens | Reviewers: Müller, Jens; Strassert, Cristian
Period of time: 01/04/2019 - 22/08/2022
Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster

Talks about the project

Site-specific metalation of DNA oligonucleotides with phosphorescent platinum(II) complexes
Müller, J. (20/09/2023)
International Symposium on Bioorganometallic Chemistry, Braunschweig
Type of talk: scientific Talk