CRC 858 A09 - Are Stereoelectronic Effects Additive or Cooperative?

Basic data for this project

Description

Stereoelectronic effects are abundant in nature and are also key elements in organic chemistry. The goal of the project is to explore whether stereoelectronic effects are additive or cooperative. To this end, various multi-vicinal fluorinated alkanes which are constructed from CHF-entities with defined configuration will be studied. These little explored functionalities will eventually be incorporated into catalytically and biologically interesting compounds. Realization of this project demands for a multidisciplinary approach within the frame of the SFB: syntheses and structural analysis will challenge the analytical institutions of the WWU Münster and also computational chemistry will be used to understand and quantify the addressed interactions. Finally, the novel compounds will be applied to enantioselective catalysis.