CRC 1348 B03 - High-resolution analysis of membrane domain formation during neuronal polarization
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2018 - 31/12/2021 | 1st Funding period
Description
The extension of the axon requires an expansion of the cell membrane by the exocytosis of specialized vesicles. We have identified the GEF βPix as a novel regulator of neuronal polarity and shown that it activates the Rho GTPase TC10 that promotes axon formation through its interaction with the exocyst complex. In our project, we will use high-resolution live cell imaging and optogenetic manipulation to understand how βPix and TC10 regulate membrane dynamics during neuronal polarization through the exocyst complex.
Keywords: Biologie; Neurobiologie; Verhaltensbiologie
Website of the project: http://sfb1348.uni-muenster.de
Funding identifier: SFB 1348/1 B03
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Busch, Karin | Professur für Zoologie und Molekulare Zellbiologie (Prof. Busch) |
| Püschel, Andreas | Professur für Molekulare Zellbiologie (Prof. Püschel) |
Applicants from the University of Münster
| Busch, Karin | Professur für Zoologie und Molekulare Zellbiologie (Prof. Busch) |
| Püschel, Andreas | Professur für Molekulare Zellbiologie (Prof. Püschel) |