CRC 1348 - B03: High-resolution analysis of membrane domain formation during neuronal polarization
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2018 - 31/12/2021 | 1st Funding period
Description
The extension of the axon requires an expansion of the cell membrane by the exocytosis of specialized vesicles. We have identified the GEF βPix as a novel regulator of neuronal polarity and shown that it activates the Rho GTPase TC10 that promotes axon formation through its interaction with the exocyst complex. In our project, we will use high-resolution live cell imaging and optogenetic manipulation to understand how βPix and TC10 regulate membrane dynamics during neuronal polarization through the exocyst complex.
Keywords: Biologie; Neurobiologie; Verhaltensbiologie
Website of the project: http://sfb1348.uni-muenster.de
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/394431988
Funding identifier: SFB 1348/1 B03 | DFG project number: 386797833
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Busch, Karin | |
| Püschel, Andreas |
Applicants from the University of Münster
| Busch, Karin | |
| Püschel, Andreas |
Projects of the following funding period
Duration: 01/01/2022 - 31/12/2025 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/01/2018 - 31/12/2021 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |