CRC 1348 B04 - Membrane remodeling and severing during dendrite pruning in Drosophila neurons
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2018 - 31/12/2021 | 1st Funding period
Description
Peripheral sensory neurons of Drosophila larvae prune their larval dendrites at the onset of metamorphosis through a degenerative mechanism. Dendrite pruning requires the loss of cell adhesion molecules (CAMs). We have identified membrane trafficking regulators required for pruning and CAM degradation. We propose to use these mutants to unravel the triggers and mechanisms of CAM degradation, to identify the affected membrane interfaces, and to identify the mechanisms by which interface remodeling contributes to pruning.
Keywords: Biologie; Neurobiologie; Verhaltensbiologie
Website of the project: http://sfb1348.uni-muenster.de/index.php/graduate-school
Funding identifier: SFB 1348/1 B04
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Rumpf, Sebastian | Professorship of Neuro- and Behavioral Biology (Prof. Klämbt) |
Applicants from the University of Münster
| Rumpf, Sebastian | Professorship of Neuro- and Behavioral Biology (Prof. Klämbt) |