Imaging Ageing Endothelium at the nanoscale (ImAge-D)

Basic data for this project

Description

Our understanding of endothelial cells (ECs) and their crucial role in the transfer and clearance of metabolites and pharmaceuticals to vital organs, especially how ECs change with ageing, is limited at the nanoscale. Current optical nanoscopes are slow and can only be used on isolated, typically fixed (i.e. dead) cells. Additionally, newcomers to the field must acquaint themselves with potential issues such as image reconstruction-related artefacts. The EU-funded ImAge-D project aims to remove these limitations by training 10 doctoral candidates in high-speed, high-resolution biomedical imaging tools. The project will study living ECs and their changes with ageing, focusing on physics and biomedicine concepts/skills in super-resolution imaging, analytical image reconstruction and optical micro-manipulation.