Variability and organ specificity of lymphatic vessel–dendritic cell interactions in the eye (allergic conjunctivitis)
Basic data for this project
Type of project: Subproject in DFG-joint project hosted outside University of Münster
Duration at the University of Münster: 01/04/2024 - 31/12/2027 | 1st Funding period
Description
The oak processionary moth toxin thaumetopoein (Tha) causes massive allergic responses in skin and conjunctiva. To investigate the role of dendritic cells in Tha-induced dermatitis and conjunctivitis, we will develop new mouse models based on recombinant Tha-allergens. Spatial characterization of the lymphatic vessel beds in mouse and human conjunctiva, comparison of dendritic cells migration in skin and conjunctiva and manipulation of lymph vessels in the mouse will provide the basis to probe if immune cell migration to lymph vessels during the allergic response to Tha is a target for future therapeutic intervention.
Keywords: Organ specificity; Imaging; Inlammation, Hypoxia
Website of the project: https://www.sfb1607.de/projekt/b04/
Funding identifier: SFB1607, B04
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Kiefer, Friedemann |
Applicants from the University of Münster
| Kiefer, Friedemann |
Project partners outside the University of Münster
- University Hospital CologneGermany
Coordinating organisations outside the University of Münster
- University of Cologne (UzK)Germany
Related main project
Duration: 01/04/2024 - 31/12/2027 Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted outside University of Münster |