CRC 1348 - A14: Dynamic and spatiotemporal control of Notch and Plexin signaling for assembling precise multicellular structures
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2026 - 31/12/2029 | 2nd Funding period
Description
The bottom-up assembly of new tissues starting from single cells is a powerful approach in tissue engineering. Here, we will develop light-controlled versions of Notch and Plexin signaling, two key pathways involved in tissue organization. By combining these optogenetic tools with micropatterned biomimetic surfaces, we aim to investigate how receptor-ligand interaction dynamics and clustering impact on signaling and cell-cell adhesions. This approach will allow us to uncover the role of Plexin signaling in tumor microenvironments and cancer metastasis, and to rationally guide the formation of 3D multicellular structures.
Keywords: Signaltransduktion; Zell-Zell-Adhäsion; tissue engineering
Website of the project: https://www.uni-muenster.de/SFB1348/en/projects/PROJECT_A14.html
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/496760808
Funding identifier: SFB 1348/3, A14 | DFG project number: 386797833
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Sánchez, Maria Florencia | European Institute of Molecular Imaging (EIMI) |
| Wegner, Seraphine Valeska | Institute of Physiological Chemistry and Pathobiochemistry |
Applicants from the University of Münster
| Sánchez, Maria Florencia | European Institute of Molecular Imaging (EIMI) |
| Wegner, Seraphine Valeska | Institute of Physiological Chemistry and Pathobiochemistry |