CRC TRR 425 - SP A01: Adherens junction and desmosome interactions in epithelial barriers in health and autoimmune disease
Basic data for this project
Type of project: Subproject in DFG-joint project hosted outside University of Münster
Duration at the University of Münster: 01/04/2026 - 31/12/2029 | 1st Funding period
Description
The sub-project investigates how adherens junctions (AJs) and desmosomes (DSMs) coordinate their composition, stability, and turnover to regulate epithelial morphogenesis and regeneration in health and disease. Combining molecular force sensors and optomechanics with 2D, 3D, and in vivo models, we investigate the organization, mechanics, and function of AJs and DSMs at the molecular, cellular, and tissue levels in simple and stratified epithelia.
Keywords: Epithelien; Zell-Zell-Verbindungen
Website of the project: https://www.uni-marburg.de/en/trr425/projects/research-area-a-desmosome-function
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/575301500
Funding identifier: TRR 425/1, A01 | DFG project number: 547068789
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Grashoff, Carsten | Professorship for quantitative cell biology |
Applicants from the University of Münster
| Grashoff, Carsten | Professorship for quantitative cell biology |
Project partners outside the University of Münster
- University Hospital CologneGermany
Coordinating organisations outside the University of Münster
- Marburg UniversityGermany