CRC 1348 - B15: The role of latrophilin in contact-stimulated mesenchymal cell migration and tissue sculpting
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2026 - 31/12/2029 | 1st Funding period
Description
During organogenesis, mesenchymal cell layers – such as smooth muscle cells in vertebrates – can actively shape organ morphology. We study muscle cells in Drosophila that sculpt the testis into a characteristic spiral. Knockdown of the adhesion G protein-coupled receptor Cirl/Latrophilin disrupts the alignment and collective migration of these cells, thereby affecting testis morphology. We investigate how Cirl/Latrophilin regulates the cytoskeleton and adhesion complexes at cell-cell interfaces to enable normal cell alignment and organ formation.
Keywords: Organogenese; Drosophila; Cirl/Latrophilin
Website of the project: https://www.uni-muenster.de/SFB1348/en/projects/PROJECT_B15.html
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/570786280
Funding identifier: SFB 1348/3, B15 | DFG project number: 386797833
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)