CRC 1348 - B11: Remodeling of tricellular junctions controls paracellular transport

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/01/2026 - 31/12/2029 | 2nd Funding period

Description

During oogenesis in oviparous animals, tricellular junctions (TCJs) in the follicular epithelium open transiently to allow passage of yolk proteins for uptake by the oocyte. This process involves remodeling of adhesion complexes and of actomyosin at cell vertices and is regulated by TGF-β signaling. We aim to identify the relevant TGF-β effectors that control actomyosin and E-Cadherin dynamics. To understand how the barrier-forming complex is assembled at the interface of three cells, we will investigate the structure of the TCJ protein Anakonda (Aka).

Keywords: Biologie; zelluläre Kontaktstellen; Bildgebung

Website of the project: https://www.uni-muenster.de/SFB1348/en/projects/PROJECT_B11.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/496763214

Funding identifier: SFB 1348/3, B11 | DFG project number: 386797833

Funder / funding scheme:

DFG - Collaborative Research Centre (SFB)

Project management at the University of Münster

Luschnig, Stefan

Professur für Morphogenese tubulärer Organe (Prof. Luschnig)

Applicants from the University of Münster