CRC 1348 - B11: Remodeling of tricellular junctions controls paracellular transport
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2026 - 31/12/2029 | 2nd Funding period
Description
During oogenesis in oviparous animals, tricellular junctions (TCJs) in the follicular epithelium open transiently to allow passage of yolk proteins for uptake by the oocyte. This process involves remodeling of adhesion complexes and of actomyosin at cell vertices and is regulated by TGF-β signaling. We aim to identify the relevant TGF-β effectors that control actomyosin and E-Cadherin dynamics. To understand how the barrier-forming complex is assembled at the interface of three cells, we will investigate the structure of the TCJ protein Anakonda (Aka).
Keywords: Biologie; zelluläre Kontaktstellen; Bildgebung
Website of the project: https://www.uni-muenster.de/SFB1348/en/projects/PROJECT_B11.html
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/496763214
Funding identifier: SFB 1348/3, B11 | DFG project number: 386797833
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Luschnig, Stefan |
Applicants from the University of Münster
| Luschnig, Stefan |
Projects of the previous funding period
Duration: 01/01/2022 - 31/12/2025 | 1st Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/01/2026 - 31/12/2029 | 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |