CRC 1348 - A12: Integrin Subtype-specific Organization and Force Transduction
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/01/2026 - 31/12/2029 | 3rd Funding period
Description
This project will investigate how distinct cell adhesion interfaces sense mechanochemical signals at the plasma membrane and transmit them to the nuclear envelope to modulate nuclear mechanotransduction. Experiments will employ various molecular force-sensing technologies, single-cell transcriptomics and real-time imaging of transcriptional kinetics to uncover communication principles between plasma membrane and the nucleus and assess the impact of this communication on cell state regulation.
Keywords: Biologie; zelluläre Kontaktstellen; Bildgebung
Website of the project: https://www.uni-muenster.de/SFB1348/en/projects/PROJECT_A12.html
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/423280617
Funding identifier: SFB 1348/3, A12 | DFG project number: 386797833
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Grashoff, Carsten |
Applicants from the University of Münster
| Grashoff, Carsten |
Project partners outside the University of Münster
- Max Planck Institute for Molecular BiomedicineGermany
Projects of the previous funding period
Duration: 01/01/2022 - 31/12/2025 | 2nd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Subproject in DFG-joint project hosted at University of Münster |
Related main project
Duration: 01/01/2026 - 31/12/2029 | 3rd Funding period Funded by: DFG - Collaborative Research Centre Type of project: Main DFG-project hosted at University of Münster |