CRC 1348 - A08: Molecular parameters for the dynamic assembly of Hedgehog signaling platforms

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/01/2026 - 31/12/2029 | 3rd Funding period

Description

The transporter protein Dispatched (Disp) solubilizes lipidated Hedgehog (Hh) morphogen proteins from the plasma membrane (PM) of Hh-producing cells. In the previous funding period, we showed that Disp extracts the cholesteroylated C-terminal Hh peptide and transports it to high-density lipoproteins (HDL), while the N-terminal peptide anchor is cleaved by the protease ADAM10. Additionally, we found that Disp also transports free PM cholesterol to HDL, revealing a non-canonical role of Disp in cholesterol homeostasis. We will now investigate the consequences of the two Disp functions for Hh morphogen transport and cellular physiology.

Keywords: Biologie; zelluläre Kontaktstellen; Bildgebung

Website of the project: https://www.uni-muenster.de/SFB1348/en/projects/PROJECT_A08.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/394344789

Funding identifier: SFB 1348/3, A08 | DFG project number: 386797833

Funder / funding scheme: