CRC 1348 - A05: Lipid-mediated activation of protein kinases during cell polarization

Basic data for this project

Type of project: Subproject in DFG-joint project hosted at University of Münster

Duration at the University of Münster: 01/01/2026 - 31/12/2029 | 3rd Funding period

Description

We study the dynamic interaction of the basolateral polarity regulators LKB1 and Par-1 with phospholipids of the plasma membrane using mammalian cell culture models and Drosophila in vivo experiments. Furthermore, we apply cryo-electron microscopy and molecular simulations to resolve the molecular mechanism of LKB1/Par-1-phospholipid interaction and its impact on protein localization and kinase activation to understand the establishment of apical-basal polarity.

Keywords: Biologie; zelluläre Kontaktstellen; Bildgebung

Website of the project: https://www.uni-muenster.de/SFB1348/en/projects/PROJECT_A05.html

DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/394342809

Funding identifier: SFB 1348/3, A05 | DFG project number: 386797833

Funder / funding scheme: