CRC 1748 - B05: The role of the MHC for fertilisation and infertility from a fish perspective
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/04/2026 - 31/12/2029 | 1st Funding period
Description
The interaction of sperm and egg and, thus, the fertilisation process seems to involve the major histocompatibility complex (MHC), which is crucial for the initiation of the adaptive immune response. Using two fish models, the relevance of optimal individual MHC diversity for spermatogenesis, sperm function, and sperm-egg interaction will be experimentally tested. This approach is combined with the analysis of human genomic datasets. Thereby, insights on the role of MHC in the fertilisation process and of genetic variants affecting the function of the complex in male infertility will be gained.
Keywords: Histokompatibilitätskomplex; Spermien
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/574758985
Funding identifier: SFB 1748/1, B05 | DFG project number: 549467913
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Kurtz, Joachim | Research Group Animal Evolutionary Ecology (Prof. Kurtz) |
| Peuß, Robert | Professur für Tierphysiologie (Prof. Rohner) |
Applicants from the University of Münster
| Kurtz, Joachim | Research Group Animal Evolutionary Ecology (Prof. Kurtz) |
| Peuß, Robert | Professur für Tierphysiologie (Prof. Rohner) |