CRC 1748 - B04: In situ structural analysis of the human CatSper-channel complex
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/04/2026 - 31/12/2029 | 1st Funding period
Description
Loss of CatSper function is a common channelopathy that leads to male infertility. To shed light on the role of CatSper in human sperm in both health and disease, high-resolution structures of in-cell assembled CatSper as well as its spatial arrangement along the flagellum will be determined, using cutting-edge cryo-electron tomography (cryo-ET) and tailored structure-function analyses. Moreover, by cryo-ET of the channel in sperm from patients lacking the CATSPER2 gene, i.e., the most common cause of CatSper-related infertility, the molecular pathology leading to loss of CatSper function will be elucidated.
Keywords: Spermienmotilität; CatSper; Ionenkanal
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/574758761
Funding identifier: SFB 1748/1, B04 | DFG project number: 549467913
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Gatsogiannis, Christos | Center for Soft Nanoscience (SoN) |
Applicants from the University of Münster
| Gatsogiannis, Christos | Center for Soft Nanoscience (SoN) |