CRC1748 - B02: Deciphering the role of adenylate kinases and microtubule inner proteins in male fertility
Basic data for this project
Type of project: Subproject in DFG-joint project hosted at University of Münster
Duration at the University of Münster: 01/04/2026 - 31/12/2029 | 1st Funding period
Description
Flagellar and ciliary motor proteins use ATP as energy source, rendering the maintenance of adenine nucleotide homeostasis essential for sperm motility and male fertility. This project aims to identify genetic variants affecting adenine nucleotide homeostasis in men with impaired sperm motility/motile ciliopathies. Thus, the flagellar adenine nucleotide-homeostasis circuit will be elucidated to facilitate the analysis of pathogenic variants underlying male infertility and to characterise the molecular machinery governing flagellar beating at high resolution. The insights gained will aid the diagnosis, counselling, and treatment of affected men.
Keywords: Spermienmotilität; Mikrotubuli
DFG-Gepris-ID: https://gepris.dfg.de/gepris/projekt/574758499
Funding identifier: SFB 1748/1, B02 | DFG project number: 549467913
Funder / funding scheme:
- DFG - Collaborative Research Centre (SFB)
Project management at the University of Münster
| Omran, Heymut | University Children's Hospital - Department for General Paediatrics |
Applicants from the University of Münster
| Omran, Heymut | University Children's Hospital - Department for General Paediatrics |