CRC1748 - B02: Deciphering the role of adenylate kinases and microtubule inner proteins in male fertility

Basic data for this project

Description

Flagellar and ciliary motor proteins use ATP as energy source, rendering the maintenance of adenine nucleotide homeostasis essential for sperm motility and male fertility. This project aims to identify genetic variants affecting adenine nucleotide homeostasis in men with impaired sperm motility/motile ciliopathies. Thus, the flagellar adenine nucleotide-homeostasis circuit will be elucidated to facilitate the analysis of pathogenic variants underlying male infertility and to characterise the molecular machinery governing flagellar beating at high resolution. The insights gained will aid the diagnosis, counselling, and treatment of affected men.