University of Münster
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Dr. Gudrun Elisabeth Würthwein

No current affiliations available for this person. The person is no longer active at the university.

Publications

Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia
Alaeddin Khalil, Gudrun Würthwein, Jana Golitsch, Georg Hempel, Manfred Fobker, Joachim Gerss, Anja Möricke, Martin Zimmermann, Petr Smisek, Massimo Zucchetti, Christa Nath, Andishe Attarbaschi, Arend Von Stackelberg, Nicola Gökbuget, Carmelo Rizzari, Valentino Conter, Martin Schrappe, Joachim Boos, Claudia Lanvers-Kaminsky (2022)
In: Haematologica, 107(1).
Research article (journal)
Impact of Antibodies Against Polyethylene Glycol on the Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukaemia: A Population Pharmacokinetic Approach
Siebel C, Lanvers-Kaminsky C, Alten J, Smisek P, Nath CE, Rizzari C, Boos J, Würthwein G (2021)
In: European Journal of Drug Metabolism and Pharmacokinetics, 2021.
Research article (journal)
Population Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukemia: Treatment Phase Dependency and Predictivity in Case of Missing Data
Würthwein G, Lanvers-Kaminsky C, Siebel C, Gerß J, Möricke A, Zimmermann M, Stary J, Smisek P, Schrappe M, Rizzari C, Zucchetti M, Hempel G, Wicha SG, Boos J (2021)
In: European Journal of Drug Metabolism and Pharmacokinetics, 46(2).
Research article (journal)
Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure
Siebel C, Würthwein G, Lanvers-Kaminsky C, André N, Berthold F, Castelli I, Chastagner P, Doz F, English M, Escherich G, Frühwald MC, Graf N, Groll AH, Ruggiero A, Hempel G, Boos J (2020)
In: BMC pharmacology & toxicology, 21(1).
Research article (journal)
Therapeutic Drug Monitoring of Asparaginase: Intra-individual Variability and Predictivity in Children With Acute Lymphoblastic Leukemia Treated With PEG-Asparaginase in the AIEOP-BFM Acute Lymphoblastic Leukemia 2009 Study
Würthwein G, Lanvers-Kaminsky C, Gerss J, Möricke A, Zimmermann M, Stary J, Smisek P, Attarbaschi A, Nath C, Zucchetti M, Rizzari C, Schrappe M, Boos J (2020)
In: Therapeutic Drug Monitoring, 42(3).
Research article (journal)
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Projects

Point-of-care Microfluidic Device for Quantification of Chemotherapeutic Drugs in Small Body Fluid Samples by Highly Selective Nanoparticle Extraction and… (DiaChemo)
Duration: 01/01/2016 - 30/04/2019
Funded by: EC H2020 - Research and innovation actions
Type of project: EU-project hosted outside University of Münster
AIEOP-BFM ALL 2009 International collaborative treatment protocol for children and adolescents with actue lymphoblastic leukemia (AIEOP-BFM ALL 2009)
Duration: 01/07/2010 - 31/12/2019
Funded by: Baxalta Deutschland GmbH
Type of project: Individual project
European Paediatric Oncology Off-Patent Medicines Consortium Phase II pharmacokinetic study to assess the age-dependency in the clearance of doxorubicin in… (EPOC-MS-001-Doxo)
Duration: 01/02/2009 - 31/10/2013
Funded by: EC FP 7 - Small or medium-scale focused research project
Type of project: EU-project hosted outside University of Münster