University of Münster
CRIS@UM
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Johanna Freundt

Current affiliations

Publications

Selective titin cleavage disrupts cardiac mechanical homeostasis to drive heart failure and fibrosis
Freundt, Johanna K.; Hartmann, Paulina; Loescher, Christine M.; Unger, Andreas; Koser, Franziska; Klotz, Annika J.; Wildschütz, Lena; Wachsmuth, Lydia; Hille, Susanne; Door, Michaela M.; Helfen, Anne; Holtmeier, Richard; Faber, Cornelius; Kirk, Jonathan A.; Hoerr, Verena; Müller, Oliver J.; Linke, Wolfgang A.  (2026)
In: Nature Cardiovascular Research. doi:10.1038/s44161-026-00829-z
Research article (journal) | Peer reviewed | Published
Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix
Freundt, Johanna K; Loescher, Christine M; Unger, Andreas; Hessel, Anthony L; Kühn, Michel; Koser, Franziska; Linke, Wolfgang A  (2023)
In: Nature Cardiovascular Research, 2(11), 991-1002. doi:10.1038/s44161-023-00348-1
Research article (journal) | Peer reviewed | Published
Histone deacetylase inhibition by Entinostat for the prevention of electrical and structural remodeling in heart failure
Freundt JK, Frommeyer G, Spieker T, Wötzel F, Grotthoff JS, Stypmann J, Hempel G, Schäfers M, Jacobs AH, Eckardt L, Lange PS (2019)
In: BMC pharmacology & toxicology, 2019(20(1)). doi:10.1186/s40360-019-0294-x
Research article (journal) | Peer reviewed | Published
Titin as a force-generating muscle protein under regulatory control
Freundt, Johanna K; Linke, Wolfgang A.  (2019)
In: Journal of Applied Physiology, 126(5), 1474-1482. doi:10.1152/japplphysiol.00865.2018
Review article (journal) | Peer reviewed | Published
The Transcription Factor ATF4 Promotes Expression of Cell Stress Genes and Cardiomyocyte Death in a Cellular Model of Atrial Fibrillation.
Freundt, Johanna K; Frommeyer, Gerrit; Wötzel, Fabian; Huge, Andreas; Hoffmeier, Andreas; Martens, Sven; Eckardt, Lars; Lange, Philipp S  (2018)
In: BioMed Research International, eCollection 2018. doi:10.1155/2018/3694362
Research article (journal) | Peer reviewed | Published