Professor Dr. Karl-Heinz Klempnauer

No current affiliations available for this person. The person is no longer active at the university.

Curriculum Vitae (CV)

Molekularbiologie

Academic Education
1989	Habilitation
1981	PhD thesis: "Studien zur Reifung von neurepliziertem Chromatin des Virus SV40 und seiner Wirtszelle" ("Maturation of newly replicated chromatin of simian virus 40 and its host cell") supervised by Prof. Dr. R. Knippers, University of Konstanz
1976	Diploma thesis in biology
1971 - 1976	Study of biology at the University of Cologne
1971	Abitur
Work Experience
since 1997	Professor of biochemistry (molecular biology), Institute of Biochemistry, WWU Münster
1990 - 1997	Head of an independent research group the Hans Speman laboratory Max Planck Institute of Immunobiology at Freiburg
1989 - 1990	Heisenberg scholarship of the Deutsche Forschungsgemeinschaft, DFG ZMBH, University of Heidelberg
1984 - 1989	Research associate at the Center of Molecular Biology (Zentrum für Molekulare Biologie, ZMBH) in the group of Prof. A.E. Sippel, University of Heidelberg
1981 - 1984	Postdoctoral research fellow in the laboratory of Prof. Dr. J.M. Bishop, University of California, San Francisco

Publications

Natural Products with Antitumor Potential targeting the MYB-C/EBPbeta-p300 Transcription Module Schmidt TJ, Klempnauer K-H. (2022) In: Molecules, 27 Type of Publication: Research article (journal)
PDCD4 controls the G1/S-phase transition in a telomerase-immortalized epithelial cell line and affects the expression level and translation of multiple mRNAs Haas A, Nilges BS, Leidel SA, Klempnauer K-H (2020) In: Scientific Reports, 2020 Type of Publication: Research article (journal)
Activation of the oncogenic transcription factor B-Myb via multisite phosphorylation and prolyl cis/trans isomerization. Werwein E, Cibis H, Hess D, Klempnauer KH (2019) In: Nucleic Acids Research, 47 Type of Publication: Research article (journal)
A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity. Yusenko M, Jakobs A, Klempnauer KH (2018) In: Scientific Reports, 8 Type of Publication: Research article (journal)
1. The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression. Coulibaly A, Haas A, Steinmann S, Jakobs A, Schmidt TJ, Klempnauer KH. (2018) In: PloS one, 13 Type of Publication: Research article (journal)

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Projects

Development of small molecule inhibitors of the transcription factor C/EBPß Duration: 01/01/2019 - 31/12/2020 Funded by: José Carreras Leukämie-Stiftung Type of project: Individual project
Untersuchungen zum anti-leukämischen Potential niedermolekularer Inhibitoren C/EBPß Duration: 01/03/2018 - 29/02/2020 Funded by: Deutsche Krebshilfe e.V. Type of project: Individual project
Untersuchungen zur Funktion des Transkriptionsfaktors B-Myb in der G2/M-Phase des Zellzyklus Duration: 01/07/2017 - 30/06/2019 Funded by: Wilhelm Sander-Stiftung Type of project: Individual project
Inhibition of transcription factor c-Myb with small-molecule inhibitors Duration: 01/01/2017 - 31/12/2019 Funded by: Else Kröner-Fresenius-Foundation Type of project: Individual project
Charakterisierung der Target RNAs des Tumor Supressor Proteins Pdcd4 Duration: 01/07/2016 - 30/06/2019 Funded by: DFG - Individual Grants Programme Type of project: Individual project

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Doctorates

Investigations on the Influence of selected Sesquiterpene Lactones on the Trypanothione System of Trypanosoma brucei (Thesis written in German) Candidate: Lenz, Mairin \| Supervisors: Schmidt, Thomas J. Klempnauer, Karl-Heinz \| Reviewers: Schmidt, Thomas J. Klempnauer, Karl-Heinz Period of time: 01/12/2014 - 22/10/2018 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Complex Regulation of Secondary Metabolism in the Phytopathogenic Fungus Fusarium fujikuroi Candidate: Dr. Rösler, Sarah M. \| Supervisors: Prof. Dr. Humpf, Hans-Ulrich Prof. Dr. Tudzynski, Bettina Period of time: 01/01/2013 - 31/07/2016 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Natural products as Inhibitors of c-Myb-dependent Transcription Processes (Thesis written in German) Candidate: Schomburg, Caroline \| Supervisors: Schmidt, Thomas J.; Klempnauer, Karl-Heinz \| Reviewers: Schmidt, Thomas J.; Klempnauer, Karl-Heinz Period of time: 01/11/2009 - 09/04/2013 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Identifikation und Charakterisierung der nukleären Funktion und DNA-Interaktion von RGS2 in myeloischen Zellen Candidate: Rehage, Maike \| Supervisors: Klempnauer, Karl-Heinz Period of time: until 21/10/2011 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
B-Myb in der zellulären Antwort auf DNA-Schäden Candidate: Džuganova, Monika \| Supervisors: Klempnauer, Karl-Heinz Period of time: until 07/06/2011 Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster

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