Research Group Evolutionary Functional Genomics (Jun.-Prof. Acquisti)

StatusOrganisation is ended
Phone number+49 251 83-21027
Fax number+49 251 83-24668
Address
Hüfferstrasse 1
48149 Münster
Germany

Profile

A fundamental link between genomes and ecosystems is represented by the availability of resources: genes and proteins are macromolecules constituted of atoms that are incorporated into the organisms via bio-geochemical cycles operating at the ecosystem level. Therefore, the availability of the different atomic building blocks of nucleotides and amino acids may in principle represent one of the forces shaping molecular evolution in natural ecosystems. Indeed, recent evidence suggests a pivotal, yet under-explored role of the availability of nitrogen and phosphorus, that are typically limiting in natural ecosystems and are fundamental components of nucleotides and amino acids. In this framework, our group focuses on a question of central importance in the integration of the evolutionary and ecosystem perspectives: the cost of resource acquisition from the environment and the consequences of such environmental limitations on the molecular architecture of the organisms. We integrate concepts and methods from molecular evolution and ecology to measure the strength of selection induced by nutrient constraints, and to determine the time scale on which this ecological factor is evolutionarily relevant.

Publications

Elser JJ, Acquisti C, Kumar S (2011)
In: Trends in Ecology & Evolution26(1)38-44. doi:10.1016/j.tree.2010.10.006
Research article (journal) | Published
He F, Chen WH, Collins S, Acquisti C, Goebel U, Ramos-Onsins S, Lercher MJ, de Meaux J (2010)
In: Genetics185(2)695-701. doi:10.1534/genetics.110.114629
Research article (journal) | Published
Acquisti C, Kumar S, Elser JJ (2009)
In: Proceedings of the Royal Society B: Biological Sciences276(1667)2605-2610. doi:10.1098/rspb.2008.1960
Research article (journal) | Published
Acquisti C, Elser JJ, Kumar S (2009)
In: Molecular Biology and Evolution26(5)953-6. doi:10.1093/molbev/msp038
Research article (journal) | Published
Collins S, de Meaux J, Acquisti C (2007)
In: Genetics176(2)1089-1099. doi:10.1534/genetics.107.072926
Research article (journal) | Published
Show all publications (11)

Projects

Duration: 01/01/2013 - 31/12/2018
Funded by: Santander Consumer Bank AG
Type of project: Individual project
Duration: 22/07/2010 - 21/07/2015
Funded by: Volkswagen Foundation - Evolutionary Biology
Type of project: Individual project

Promotionen

The role of nutrient limitation in shaping genome composition in prokaryotes: an experimental evolution approach
Candidate: Henze, Stefanie | Supervisors: Acquisti, Claudia
Period of time: ???
Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
The impact of nitrogen deprivation on genome evolution in Escherichia coli
Candidate: Henze, Stefanie | Supervisors: Acquisti, Claudia; Dobrindt, Ulrich
Period of time: until 30/06/2016
Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
On the evolution of complex genetic diseases
Candidate: Preuss, Christoph | Supervisors: Stoll, Monika; Bornberg-Bauer, Erich; Acquisti, Claudia
Period of time: 03/06/2008 - 16/12/2011
Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster

Parent organisational units