Development and validation of a bioanalytical method for the quantification of methotrexate from serum and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS.

Opitz P, Fobker M, Fabian J, Hempel G (2024)

In: Journal of Chromatographic Science, 1715, 464610. doi:10.1016/j.chroma.2023.464610

Research article (journal) | Peer reviewed | Published

Synthesis, activity, metabolic stability and cell permeability of new cytosolic phospholipase A2α inhibitors with 1-indolyl-3-phenoxypropan-2-one structure.

Subeska A; Voundi ME; Hanekamp W; Mulac D; Langer K; Lehr M (2023)

In: Bioorganic and Medicinal Chemistry Letters, 92, 129374-129374. doi:10.1016/j.bmcl.2023.129374

Research article (journal) | Peer reviewed | Published

Hexafluoroisopropyl carbamates as selective MAGL and dual MAGL/FAAH inhibitors: Biochemical and physicochemical properties.

Barth, M.; Rudolph, S.; Kampschulze, J.; Meyer zu Vilsendorf, I.; Hanekamp, W.; Mulac, D.; Langer, K.; Lehr, M. (2022)

In: ChemMedChem, 17, e2021007. doi:10.1002/cmdc.202100757

Research article (journal) | Peer reviewed | Published

Evaluation of inhibitors of the arachidonic acid cascade with intact platelets using an on-line dilution and on-line solid phase extraction HPLC-MS method

Fabian J, Mergemeier K, Lehr M (2021)

In: ((Bitte Journal prüfen)), 155.

Research article (journal) | Peer reviewed | Published

Acylated 1H-1,2,4-triazol-5-amines targeting human coagulation factor XIIa and thrombin: Conventional and microscale synthesis, anticoagulant properties, and mechanism of action

Korff M, Imberg L, Will JM, Bückreiß N, Kalinina SA, Wenzel BM, Kastner GA, Daniliuc CG, Barth M, Ovsepyan RA, Butov KR, Humpf HU, Lehr M, Panteleev MA, Poso A, Karst U, Steinmetzer T, Bendas G, Kalinin DV. (2020)

In: Journal of Medicinal Chemistry, 63, 13159-13186.

Research article (journal) | Peer reviewed | Published

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Development and validation of a bioanalytical method for the quantification of methotrexate from serum and capillary blood using volumetric absorptive microsampling (VAMS) and on-line solid phase extraction (SPE) LC-MS. Opitz P, Fobker M, Fabian J, Hempel G (2024) In: Journal of Chromatographic Science, 1715, 464610. doi:10.1016/j.chroma.2023.464610 Research article (journal) \| Peer reviewed \| Published
HPLC fluorescence assay for measuring the activity of NAPE-PLD and the action of inhibitors affecting this enzyme. Lange, Thomas; Depmeier, Tim; Strünker, Timo; Lehr, Matthias (2023) In: Journal of Pharmaceutical and Biomedical Analysis, 229. doi:10.1016/j.jpba.2023.115354 Research article (journal) \| Peer reviewed \| Published
Synthesis, activity, metabolic stability and cell permeability of new cytosolic phospholipase A2α inhibitors with 1-indolyl-3-phenoxypropan-2-one structure. Subeska A; Voundi ME; Hanekamp W; Mulac D; Langer K; Lehr M (2023) In: Bioorganic and Medicinal Chemistry Letters, 92, 129374-129374. doi:10.1016/j.bmcl.2023.129374 Research article (journal) \| Peer reviewed \| Published
Synthesis and pharmacokinetic properties of novel cPLA2α inhibitors with 1-(carboxyalkylpyrrolyl)-3-aryloxypropan-2-one structure. Subeska A; Althaus J; Hake T; Hanekamp W; Bettenworth D; Mulac D; Langer K; Lehr M (2023) In: Bioorganic & Medicinal Chemistry, 77, 117110-117110. doi:10.1016/j.bmc.2022.117110 Research article (journal) \| Peer reviewed \| Published
Hexafluoroisopropyl carbamates as selective MAGL and dual MAGL/FAAH inhibitors: Biochemical and physicochemical properties. Barth, M.; Rudolph, S.; Kampschulze, J.; Meyer zu Vilsendorf, I.; Hanekamp, W.; Mulac, D.; Langer, K.; Lehr, M. (2022) In: ChemMedChem, 17, e2021007. doi:10.1002/cmdc.202100757 Research article (journal) \| Peer reviewed \| Published
High performance liquid chromatographic assays with UV-detection for evaluation of inhibitors of acetylcholinesterase and butyrylcholinesterase Michels G, Lehr M (2021) In: ((Bitte Journal prüfen)), 44. doi:10.1080/10826076.2021.1925908 Research article (journal) \| Peer reviewed \| online first
Evaluation of inhibitors of the arachidonic acid cascade with intact platelets using an on-line dilution and on-line solid phase extraction HPLC-MS method Fabian J, Mergemeier K, Lehr M (2021) In: ((Bitte Journal prüfen)), 155. Research article (journal) \| Peer reviewed \| Published
Aryl N-[w-(6-fluoroindol-1-yl)alkyl]carbamates as inhibitors of fatty acid amide hydrolase, monoacylglycerol lipase and butyrylcholinesterase: Structure-activity relationships and hydrolytic stability Rudolph S, Dahlhaus H, Hanekamp W, Albers C, Barth M, Michels G, Friedrich D, Lehr M (2021) In: ACS Omega, 6, 13466-13483. Research article (journal) \| Peer reviewed \| Published
Acylated 1H-1,2,4-triazol-5-amines targeting human coagulation factor XIIa and thrombin: Conventional and microscale synthesis, anticoagulant properties, and mechanism of action Korff M, Imberg L, Will JM, Bückreiß N, Kalinina SA, Wenzel BM, Kastner GA, Daniliuc CG, Barth M, Ovsepyan RA, Butov KR, Humpf HU, Lehr M, Panteleev MA, Poso A, Karst U, Steinmetzer T, Bendas G, Kalinin DV. (2020) In: Journal of Medicinal Chemistry, 63, 13159-13186. Research article (journal) \| Peer reviewed \| Published
HPLC-UV assay for the evaluation of inhibitors of plasma amine oxidase using crude bovine plasma Mergemeier K, Galster F, Lehr M (2019) In: Journal of Enzyme Inhibition and Medicinal Chemistry, 34(144-149). Research article (journal) \| Peer reviewed \| Published