Mercury Speciation Analysis: Interaction with Blood Proteins and Spatial Microanalysis in Cells
Basic data of the doctoral examination procedure
Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Period of time: 01/11/2012 - 31/12/2015
Status: completed
Candidate: Hogeback, Jens
Doctoral subject: Chemie
Doctoral degree: Dr. rer. nat.
Awarded by: Department 12 - Chemistry and Pharmacy
Supervisors: Karst, Uwe; Schwerdtle, Tanja
Description
The aim of this thesis is the development and application of analytical methods to better understand the fate and behavior of mercury species in blood as well as the evaluation of the distribution processes on a molecular level. Therefore, methods of speciation analysis using liquid chromatography (LC) complementarily coupled to both electrospray ionization (ESI) and inductively coupled plasma-mass spectrometry (ICP-MS) are employed for the investigation of the interaction of mercury species with different blood fractions and blood proteins. The uptake of mercury into cells is investigated by means of laser ablation (LA) coupled to ICP-MS.
Promovend*in an der Universität Münster
| Hogeback, Jens | Professur für Analytische Chemie (Prof. Karst) |
Supervision at the University of Münster
| Karst, Uwe | Professur für Analytische Chemie (Prof. Karst) |
| Schwerdtle, Tanja | Institute of Food Chemistry |
Publications resulting from doctoral examination procedure
Hogeback J., Schwarzer M., Wehe C., Sperling M., Karst U. (2016) In: Metallomics, 8(1), 101-107. doi:10.1039/c5mt00186b Research article (journal) | Peer reviewed | Published |