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Functional analysis of Syndecan-1, a novel target of miR-10b, in breast cancer progression

Basic data of the doctoral examination procedure

Doctoral examination procedure finished at: Doctoral examination procedure at University of Münster
Period of time: 05/01/2008 - 19/07/2011
Status: completed
Candidate: Abdel-Aziz Ibrahim, Sherif
Doctoral subject: Biologie
Doctoral degree: Dr. rer. nat.
Awarded by: Department 13 - Biology
Supervisors: Götte, Martin; Liebau, Eva; Greve, Burkhard

Supervision at the University of Münster

Götte, Martin
Department of Gynecology and Obstetrics
Greve, Burkhard
Clinic for Radiotherapy
Liebau, Eva
Professorship for Animal Physiology (Prof. Liebau)

Projects in which the doctoral examination procedure takes/took place

Syndecan-1 as a new thrapeutic target in breast cancer
Duration: 01/01/2009 - 31/12/2011
Funded by: Foundations / Trusts
Type of project: Individual project

Publications resulting from doctoral examination procedure

Association of Syndecan-1 expression with cell adhesion, migration and resistance to irradiation in breast cancer
Hassan H, Gotte M, Ibrahim SA, Eich HT, Greve B (2013)
In: Strahlentherapie und Onkologie, 189 1.
Research article (journal) | Peer reviewed | Published
Syndecan-1 modulates ?-integrin-dependent and interleukin-6-dependent functions in breast cancer cell adhesion, migration, and resistance to irradiation.
Hassan H, Greve B, Pavao MS, Kiesel L, Ibrahim SA, Götte M (2013)
In: The FEBS Journal, 280(10), 2216-27.
Research article (journal) | Published
Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism.
Ibrahim SA, Yip GW, Stock C, Pan JW, Neubauer C, Poeter M, Pupjalis D, Koo CY, Kelsch R, Schüle R, Rescher U, Kiesel L, Götte M (2012)
In: International Journal of Cancer, 131(6).
Research article (journal) | Peer reviewed | Published
Overexpression of the Sulfotransferase HS3ST2 leads to increased MMP-activity and increased motility and invasiveness of MDA-MB-231 breast cancer cells
Gasser ES, Ibrahim SA, Kumar AV, Spillmann D, Stock C, Kiesel L, Yip GW, Gotte M (2011)
In: International Journal of Molecular Medicine, 28.
Research article (journal) | Peer reviewed | Published
miR-145-dependent targeting of Junctional Adhesion Molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness.
Götte M, Mohr C, Koo CY, Stock C, Vaske AK, Viola M, Ibrahim SA, Peddibhotla S, Teng YH, Low JY, Ebnet K, Kiesel L, Yip GW (2010)
In: Oncogene, 29(50), 6569-6580.
Research article (journal) | Peer reviewed | Published
Show all publications (10)