Fetal Growth Restriction: Comparison of Biometric Parameters

Marchand C, Köppe J, Köster HA, Oelmeier K, Schmitz R, Steinhard J, Fruscalzo A, Kubiak K

Forschungsartikel (Zeitschrift) | Peer reviewed

Zusammenfassung

The aim of this study was to identify growth-restricted fetuses using biometric parameters and to assess the validity and clinical value of individual ultrasound parameters and ratios, such as transcerebellar diameter/abdominal circumference (TCD/AC), head circumference/abdominal circumference (HC/AC), and femur length/abdominal circumference (FL/AC). In a retrospective single-center cross-sectional study, the biometric data of 9292 pregnancies between the 15th and 42nd weeks of gestation were acquired. Statistical analysis included descriptive data, quantile regression estimating the 10th and 90th percentiles, and multivariable analysis. We obtained clinically noticeable results in predicting small-for-gestational-age (SGA) and fetal growth restriction (FGR) fetuses at advanced weeks of gestation using the AC with a Youden index of 0.81 and 0.96, respectively. The other individual parameters and quotients were less suited to identifying cases of SGA and FGR. The multivariable analysis demonstrated the best results for identifying SGA and FGR fetuses with an area under the curve of 0.95 and 0.96, respectively. The individual ultrasound parameters were better suited to identifying SGA and FGR than the ratios. Amongst these, the AC was the most promising individual parameter, especially at advanced weeks of gestation. However, the highest accuracy was achieved with a multivariable model.

Details zur Publikation

FachzeitschriftJournal of personalized medicine
Jahrgang / Bandnr. / Volume12
Ausgabe / Heftnr. / Issue7
StatusVeröffentlicht
Veröffentlichungsjahr2022
DOI10.3390/jpm12071125
Link zum Volltexthttps://www.mdpi.com/2075-4426/12/7/1125
Stichwörterfetal biometry; fetal growth retardation; fetal sonographic parameters; fetal sonographic ratios; fetal ultrasound; small for gestational age

Autor*innen der Universität Münster

Köppe, Jeanette
Institut für Biometrie und Klinische Forschung (IBKF)
Oelmeier, Kathrin Johanna
Klinik für Frauenheilkunde und Geburtshilfe
Schmitz, Ralf
Klinik für Frauenheilkunde und Geburtshilfe