Neuropathic Itch: Routes to Clinical Diagnosis

Pereira MP, Wiegmann H, Agelopoulos K, Ständer S

Forschungsartikel (Zeitschrift) | Peer reviewed

Zusammenfassung

Neuropathic itch occurs due to damage of neurons of the peripheral or central nervous system. Several entities, including metabolic, neurodegenerative, orthopedic, infectious, autoimmune, malignant, and iatrogenic conditions, may affect the somatosensory system and induce neuropathic itch. Due to the complex nature of neuropathic itch, particularly concerning its clinical presentation and possible etiological factors, diagnostic work-up of this condition is challenging. A detailed medical history, especially in regard to the itch, and a comprehensive physical examination are relevant to detect characteristic signs and symptoms of neuropathic itch and to rule out other possible causes for chronic itch. Complementary diagnostic exams, especially laboratory tests, determination of the intraepidermal nerve fiber density via a skin biopsy and radiological examinations may be indicated to confirm the diagnosis of neuropathic itch and to identify underlying etiological factors. Functional assessments such as quantitative sensory testing, nerve conduction studies, evoked potentials, or microneurography may be considered in particular cases. This review article provides a comprehensive overview of the diagnostic work-up recommended for patients with neuropathic itch.

Details zur Publikation

FachzeitschriftFrontiers in medicine
Jahrgang / Bandnr. / Volume8
StatusVeröffentlicht
Veröffentlichungsjahr2021
Sprache, in der die Publikation verfasst istEnglisch
DOI10.3389/fmed.2021.641746

Autor*innen der Universität Münster

Agelopoulos, Konstantin
Klinik für Hautkrankheiten - Allgemeine Dermatologie und Venerologie -
Fernandes Lobo Pereira, Manuel Pedro
Klinik für Hautkrankheiten - Allgemeine Dermatologie und Venerologie -
Ständer, Sonja
Klinik für Hautkrankheiten - Allgemeine Dermatologie und Venerologie -
Wiegmann, Henning
Klinik für Hautkrankheiten - Allgemeine Dermatologie und Venerologie -