Anti-Shiga toxin 2 antibodies in enterohemorrhagic Escherichia coli O104:H4 infected patients may predict hemolytic uremic syndrome

Dammermann W, Mihajlov V, Middendorf B, Mellmann A, Karch H, Luth S, Ullrich S

Forschungsartikel (Zeitschrift) | Peer reviewed

Zusammenfassung

BACKGROUND AND AIM: An outbreak of Shiga toxin 2 (Stx2) producing enterohemorrhagic and enteroaggregative Escherichia coli O104:H4 infection in May 2011 in Germany caused enterocolitis and an unprecedented high 22% rate of hemolytic uremic syndrome (HUS). We hypothesized that anti-Stx2 IgM or IgG titers might predict HUS development.METHODS: Thirty-two patients infected with enterohemorrhagic Escherichia coli O104:H4 (HUS: n=23; non-HUS: n=9) were retrospectively screened for anti-Stx2 IgM/IgG and matched with clinical data regarding HUS development, fever, superinfection, dialysis, neurological symptoms, intensive care, antibiotic treatment, and plasmapheresis.RESULTS: Only HUS patients showed a prominent Stx2-specific humoral response in the early acute phase. Despite a strong trend towards prediction of HUS development, statistical analysis revealed no significant correlation between high IgM/IgG titers and further key clinical parameters such as fever, superinfection, neurological symptoms, antibiotic treatment, and plasmapheresis.CONCLUSIONS: Anti-Stx2 antibodies seem to accompany or even precede HUS development.

Details zur Publikation

Jahrgang / Bandnr. / Volume33
Ausgabe / Heftnr. / Issue7
Seitenbereich1353-1356
StatusVeröffentlicht
Veröffentlichungsjahr2018 (12.03.2018)
Sprache, in der die Publikation verfasst istEnglisch
DOI10.1111/jgh.14082
StichwörterEHEC O104:H4; HUS; Shiga toxin 2; anti-Shiga toxin 2; hemolytic uremic syndrome

Autor*innen der Universität Münster

Karch, Helge
Institut für Hygiene
Mellmann, Alexander
Institut für Hygiene
Middendorf-Bauchart, Barbara
Institut für Hygiene