Differential abnormal pattern of anterior cingulate gyrus activation in unipolar and bipolar depression: An fMRI and pattern classification approach.

Bürger, Ch., Redlich, R., Grotegerd, D., Meinert, S., Dohm, K., Schneider, I., Zaremba, D., Förster, K., Alferink, J., Bölte, J., Heindel, W. Kugel, H., Arolt, W. & Dannlowski, U.

Forschungsartikel (Zeitschrift) | Peer reviewed

Zusammenfassung

Distinguishing bipolar disorder from major depressive disorder is a major challenge in psychiatric treatment. Consequently, there has been growing interest in identifying neuronal biomarkers of disorder-specific pathophysiological processes to differentiate affective disorders. Thirty-six depressed bipolar patients, 36 depressed unipolar patients, and 36 matched healthy controls (HCs) participated in an fMRI experiment. Emotional faces served as stimuli in a matching task. We investigated neural activation towards angry, fearful, and happy faces focusing on prototypical regions related to emotion processing, ie, the amygdala and the anterior cingulate gyrus (ACG). Furthermore, we employed a whole-brain and a multivariate pattern classification analysis. Unipolar patients showed abnormally reduced ACG activation toward happy and fearful faces compared with bipolar patients and HCs respectively. Furthermore, the whole-brain analysis revealed significantly increased activation in bipolar patients compared with unipolar patients in the fearful condition in the right frontal and parietal cortex. Moreover, the multivariate pattern classification analysis yielded significant classification rates of up to 72% based on ACG activation elicited by fearful faces. Our results question the rather 'amygdalocentric' neurobiological models of mood disorders. We observed patterns of abnormally reduced ventral and supragenual ACG activation, potentially indicating impaired bottom-up emotion processing and automatic emotion regulation specifically in unipolar but not in bipolar individuals

Details zur Publikation

FachzeitschriftNeuropsychopharmacology (Neuropsychopharmacology)
Jahrgang / Bandnr. / Volume42
Ausgabe / Heftnr. / Issue7
Seitenbereich1399-1408
StatusVeröffentlicht
Veröffentlichungsjahr2017
Sprache, in der die Publikation verfasst istEnglisch
Stichwörterdepression; unipolar; bipolar; emotional face; amygdala; ACG

Autor*innen der Universität Münster

Alferink, Judith
Klinik für Psychische Gesundheit
Arolt, Volker
Klinik für Psychische Gesundheit
Bölte, Jens
Institut für Psychologie
Bürger, Christian
Klinik für Psychische Gesundheit
Dannlowski, Udo
Klinik für Psychische Gesundheit
Grotegerd, Dominik
Klinik für Psychische Gesundheit
Heindel, Walter Leonhard
Klinik für Radiologie
Koch, Katharina
Klinik für Psychische Gesundheit
Kugel, Harald
Klinik für Radiologie
Meinert, Susanne Leonie
Klinik für Psychische Gesundheit
Redlich, Ronny
Klinik für Psychische Gesundheit
Schneider, Ilona
FB 07 - Psychologie: Psychotherapie-Ambulanz
Zaremba, Dario
Klinik für Psychische Gesundheit