Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis.

Krieglstein CF, Anthoni C, Rijcken EJ, Laukötter M, Spiegel HU, Boden SE, Schweizer S, Safayhi H, Senninger N, Schürmann G

Forschungsartikel (Zeitschrift)

Zusammenfassung

The gum resin extract from Boswellia serrata (H15), an herbal product, was recently shown to have positive therapeutic effects in inflammatory bowel disease (IBD). However, the mechanisms and constituents responsible for these effects are poorly understood. This study examined the effect of the Boswellia extract and its single constituent acetyl-11-keto-beta-boswellic acid (AKBA) on leukocyte-endothelial cell interactions in an experimental model of IBD. Ileitis was induced by two subcutaneous injections of indomethacin (7.5 mg/kg) in Sprague-Dawley rats 24 h apart. Rats also received oral treatment with the Boswellia extract (H15) or AKBA at two different doses (low and high) equivalent to recommendations in human disease over 2 days. Controls received only the carriers NaHCO3 (subcutaneously) and tylose (orally). Effects of treatment were assessed by intravital microscopy in ileal submucosal venules for changes in the number of rolling and adherent leukocytes and by macroscopic and histological scoring. Increased leukocyte-endothelial cell adhesive interactions and severe tissue injury accompanied indomethacin-induced ileitis. Treatment with the Boswellia extract or AKBA resulted in a dose-dependent decrease in rolling (up to 90%) and adherent (up to 98%) leukocytes. High-dose Boswellia extract as well as both low- and high-dose AKBA significantly attenuated tissue injury scores. Oral therapy with the Boswellia extract or AKBA significantly reduces macroscopic and microcirculatory inflammatory features normally associated with indomethacin administration, indicating that the anti-inflammatory actions of the Boswellia extract in IBD may be due in part to boswellic acids such as AKBA.

Details zur Publikation

FachzeitschriftInternational Journal of Colorectal Disease (Int J Colorectal Dis)
Jahrgang / Bandnr. / Volume16
Ausgabe / Heftnr. / Issue2
Seitenbereich88-95
StatusVeröffentlicht
Veröffentlichungsjahr2001
Sprache, in der die Publikation verfasst istEnglisch
DOI10.1007/s003840100292
StichwörterRats; Male; Treatment Outcome; Comparative Study; Animals; Triterpenes; Sensitivity and Specificity; Reference Values; Inflammatory Bowel Diseases; Disease Models Animal; Plants Medicinal; Rats Sprague-Dawley; Research Support Non-U.S. Gov't. Resins Plant; Plant Extracts; Follow-Up Studies; Probability; Ileitis; Rats; Male; Treatment Outcome; Comparative Study; Animals; Triterpenes; Sensitivity and Specificity; Reference Values; Inflammatory Bowel Diseases; Disease Models Animal; Plants Medicinal; Rats Sprague-Dawley; Research Support Non-U.S. Gov't. Resins Plant; Plant Extracts; Follow-Up Studies; Probability; Ileitis

Autor*innen der Universität Münster

Anthoni, Christoph
Klinik für Allgemein- und Viszeralchirurgie
Laukötter, Mike
Klinik für Allgemein- und Viszeralchirurgie
Rijcken, Emile
Klinik für Allgemein- und Viszeralchirurgie
Senninger, Norbert
Klinik für Allgemein- und Viszeralchirurgie
Spiegel, Hans-Ullrich
Klinik für Allgemein- und Viszeralchirurgie