Asymmetric conjugate silyl transfer in iterative catalytic sequences: Synthesis of the C7-C16 fragment of (+)-neopeltolide

Hartmann E, Oestreich M

Zusammenfassung

Matched or mismatched, that is not the question! The anti,anti configuration of the C7- C16 fragment of (+)-neopeltolide is stereoselectively installed in an iterative sequence of catalyst-controlled Si group and Me group transfers, even with mismatched selectivity in the former (Si=Me2PhSi, see scheme; TBS=tert-butyldimethylsilyl).