Mutational analysis of K-ras codon 12 in blood samples of patients with acute myeloid leukemia.
Preston R, Däbritz J, Hänfler J, Oettle H
Forschungsartikel (Zeitschrift)Zusammenfassung
Mutations in K-ras are frequent in acute myeloid leukemia (AML). The association of these mutations to clinical features and their prognostic value are unclear. We used quantitative PCR with peptide nucleic acid mediated PCR clamping to specifically analyze 257 blood samples of 31 AML patients for K-ras codon 12 alterations. A total of 20 samples of nine patients harbored a K-ras mutation. The most frequent mutation was the GTT variant which causes an amino acid exchange from glycine to valine. Correlation with clinical data suggests K-ras mutations to be associated with higher age and a better response to anti-leukemic chemotherapy.
Details zur Publikation
Fachzeitschrift: Leukemia Research (Leuk Res)
Jahrgang / Bandnr. / Volume: 34
Ausgabe / Heftnr. / Issue: 7
Seitenbereich: 883-891
Status: Veröffentlicht
Veröffentlichungsjahr: 2010
Sprache, in der die Publikation verfasst ist: Englisch
Stichwörter: Leukemia Myeloid; DNA Neoplasm; Prognosis; Adult; Acute Disease; Tumor Markers Biological; Polymerase Chain Reaction; Middle Aged; DNA Mutational Analysis; Aged; Genes ras; Male; Mutation Missense; Point Mutation; Female; Amino Acid Substitution; Humans; Codon; Leukemia Myeloid; DNA Neoplasm; Prognosis; Adult; Acute Disease; Tumor Markers Biological; Polymerase Chain Reaction; Middle Aged; DNA Mutational Analysis; Aged; Genes ras; Male; Mutation Missense; Point Mutation; Female; Amino Acid Substitution; Humans; Codon
Autor*innen der Universität Münster
| Däbritz, Jan | Klinik für Kinder- und Jugendmedizin - Allgemeine Pädiatrie - |