HSV-1 viremia as a potential cause of febrile neutropenia in an immunocompromised child.

Holzinger D, Kühn J, Ehlert K, Groll AH

Forschungsartikel (Zeitschrift)

Zusammenfassung

SUMMARY: Although the standard of care in febrile neutropenic patients includes the initiation of empirical antibacterial and antifungal therapy, many patients do not respond and need further diagnostic work up and treatment. Here, we report on an immunosuppressed neutropenic patient with a prolonged episode of fever unresponsive to empirical antibacterial therapy. Herpes polymerase chain reaction revealed systemic reactivation of herpes simplex virus type 1 (HSV-1) infection and treatment with acyclovir was associated with the prompt resolution of signs and symptoms of infection. Screening for HSV in persistently febrile neutropenic patients may discover HSV reactivation that can be treated successfully by acyclovir administration.

Details zur Publikation

FachzeitschriftJournal of Pediatric Hematology/Oncology (J Pediatr Hematol Oncol)
Jahrgang / Bandnr. / Volume32
Ausgabe / Heftnr. / Issue1
StatusVeröffentlicht
Veröffentlichungsjahr2010
Sprache, in der die Publikation verfasst istEnglisch
DOI10.1097/MPH.0b013e3181b79669
StichwörterHumans; Viremia; Fever; Immunocompromised Host; Male; Virus Activation; Child; Immunosuppressive Agents; Acyclovir; Herpes Simplex; Neutropenia; Herpesvirus 1 Human; Humans; Viremia; Fever; Immunocompromised Host; Male; Virus Activation; Child; Immunosuppressive Agents; Acyclovir; Herpes Simplex; Neutropenia; Herpesvirus 1 Human

Autor*innen der Universität Münster

Ehlert, Karoline
KMT-Zentrum
Groll, Andreas Hermann
Klinik für Kinder- und Jugendmedizin - Pädiatrische Hämatologie und Onkologie - (UKM PHO)
Holzinger, Dirk
Institut für Immunologie
Kühn, Joachim
Institut für Medizinische Mikrobiologie