Pre-treatment global quality of health predicts progression free survival in metastatic kidney cancer patients treated with sorafenib or sunitinib.

Herrmann E, Gerss J, Bierer S, Köpke T, Bolenz C, Hertle L, Wülfing C

Forschungsartikel (Zeitschrift)

Zusammenfassung

PURPOSE: Our goal was to prospectively evaluate self-reported quality-of-life (QoL) during second-line therapy in 51 consecutive patients with cytokine-refractory kidney cancer treated with sorafenib or sunitinib. METHODS: QoL was assessed by the EORTC QoL questionnaire QLQ-C30 at baseline and at weeks 4, 6, 10, 12 and 16. RESULTS: Global QoL deteriorated significantly during the first 4 weeks of treatment (P < 0.0001). Patients experienced a reduction of their role, cognitive, and social function (all P < 0.0001). In addition, fatigue (P < 0.0001), nausea/vomiting (P = 0.003), and pain (P < 0.0001) as well as dyspnoea (P < 0.0001), insomnia (P = 0.026), appetite loss (P = 0.013), and diarrhoea (P < 0.0001) increased significantly. After 16 weeks, fatigue (P < 0.0001), pain (P = 0.015), appetite loss (P = 0.002) and diarrhoea (P = 0.038) were still influenced by the therapy, while all functional scales recovered. Global QoL at baseline was predictive of overall response (P = 0.006) and progression free survival (PFS) (P < 0.0001). A better physical function at baseline, a better ECOG performance status, and a low risk profile according to MSKCC risk groups correlated with a longer PFS (all P < 0.0001). No significant differences regarding QoL were found between sorafenib and sunitinib during the study period. CONCLUSIONS: Second-line therapy with sorafenib or sunitinib does not adversely affect patients global QoL after 16 weeks of treatment. Evaluation of baseline QoL can help to further stratify patients into risk groups predicting overall response and PFS.

Details zur Publikation

FachzeitschriftJournal of Cancer Research and Clinical Oncology
Jahrgang / Bandnr. / Volume135
Ausgabe / Heftnr. / Issue1
Seitenbereich61-67
StatusVeröffentlicht
Veröffentlichungsjahr2009
Sprache, in der die Publikation verfasst istEnglisch
DOI10.1007/s00432-008-0438-7

Autor*innen der Universität Münster

Bierer, Stefan
Klinik für Urologie
Herrmann, Edwin
Klinik für Urologie
Hertle, Lothar
Klinik für Urologie
Köpke, Thomas
Klinik für Urologie