Reprogramming Conformation by Fluorination: Exploring New Areas of Chemical Space (Recon)

Grunddaten zu diesem Projekt

Beschreibung

Organofluorine compounds, organic molecules containing carbon-fluorine bonds, are widely used to make high-impact pharmaceuticals, imaging agents, agrochemicals and various materials. Numerous pharmaceuticals are fluorinated to impart enhanced metabolic and oxidative stability, lipophilicity and membrane permeability. However, we have likely only seen the tip of the iceberg when it comes to the potential of organofluorine compounds. The roadblock has been limitations in controlling fluorination sites and the resulting 2D and 3D molecular architecture. RECON is working to unlock the potential of complex fluorinated compounds with rational design of structure for highly specific and unique function. Even better, these methods rely on cost-effective and commercially available fluoride feedstock.