SFB 1450 - C02: Organspezifische Phagocytose apoptotischer Zellen bei der Auflösung von Entzündungen

Grunddaten zu diesem Projekt

Beschreibung

Heterogeneous populations of tissue-resident macrophages and those recruited during inflammation develop in different organs upon acute inflammation. The aim of this project is to elucidate the specific contribution of diverse populations of macrophages to the resolution of inflammation through the phagocytosis of apoptotic cells. We will use two reporter mouse models bearing green fluorescent monocytes and macrophages, and red fluorescent neutrophils or cardiomyocytes, which will allow us to distinguish between macrophages that phagocytose neutrophils or cardiomyocytes. Combining a multiscale imaging strategy with high-throughput transcriptomics and metabolomics analyses, we expect to decode the transcriptional and metabolic pathways in macrophages that contribute to organ-specific immune responses through the phagocytosis of diverse apoptotic cellular cargos.