SFB 1450 - A05: Longitudinale Ganzkörperbildgebung und mathematische Modellierung zur Untersuchung der Dynamik von Immunzellen

Grunddaten zu diesem Projekt

Beschreibung

We develop strategies for tracking and quantifying (immune) cell populations or even single cells in long-term (days) whole-body PET studies in mice and humans. This will be achieved through novel acquisition protocols, measured and simulated phantom data, use of prior information from MRI and microscopy, mathematical modelling, and mathematical analysis of image reconstruction with novel regularization paradigms based on optimal transport). Particular applications include imaging and tracking of macrophages and neutrophils following myocardial ischemia-reperfusion or in arthritis and sepsis with a future potential to translate into clinical algorithms.