ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution

de Faria, Flavia W.; Riedel, Nicole C.; Münter, Daniel; Interlandi, Marta; Göbel, Carolin; Altendorf, Lea; Richter, Mathis; Melcher, Viktoria; Thomas, Christian; Roy, Rajanya; Schoof, Melanie; Bedzhov, Ivan; Moreno, Natalia; Graf, Monika; Hotfilder, Marc; Holdhof, Dörthe; Hartmann, Wolfgang; Bruns, Ann-Katrin; Brentrup, Angela; Liesche-Starnecker, Friederike; Maerkl, Bruno; Sandmann, Sarah; Varghese, Julian; Dugas, Martin; Pinto, Pedro H.; Balbach, Sebastian T.;Lu, I-Na; Rossig, Claudia; Soehnlein, Oliver; Canak, Aysegül; Ebinger, Martin; Schuhmann, Martin; Schittenhelm, Jens; Frühwald, Michael F.; Schüller, Ulrich; Albert, Thomas K.; Walter, Carolin; Bruder, Jan M.; Kerl, Kornelius. (2025)

In: Nature Communications, 16, 5394. doi:10.1038/s41467-025-60442-9

Research article (journal) | Peer reviewed | Published

The tumor suppressor CREBBP and the oncogene <i>MYCN</i> cooperate to induce malignant brain tumors in mice

Schoof, Melanie; Epplen, Gefion Dorothea; Walter, Carolin; Ballast, Annika; Holdhof, Doerthe; Goebel, Carolin; Neyazi, Sina; Varghese, Julian; Albert, Thomas Karl; Kerl, Kornelius; Schueller, Ulrich (2023)

In: Oncogenesis, 12(1). doi:10.1038/s41389-023-00481-3

Research article (journal) | Peer reviewed | Published

MOUSE MODELING OF PEDIATRIC MYCN GLIOMA REVEALS INTRATUMORAL HETEROGENEITY INCLUDING NEURONAL AND OLIGODENDROGLIAL LINEAGE SIGNATURES

Schoof, Melanie; Godbole, Shweta; Albert, Thomas K.; Termusch, Matthias Dot; Walter, Carolin; Ballast, Annika; Qin, Nan; Olivera, Marlene Baca; Goebel, Carolin; Neyazi, Sina; Holdhof, Dorthe; Kresbach, Catena; Epplen, Gefion Dorothea; Thaden, Vanessa; Blattner-Johnson, Mirjam; Modemann, Franziska; Afflerbach, Ann-Kristin; Eckhardt, Alicia; Muenter, Daniel; Struve, Nina; Jones, David T. W.; Remke, Marc; Neumann, Julia E.; Kerl, Kornelius; Schueller, Ulrich (2023)

In: Neuro-Oncology, 25. doi:10.1093/neuonc/noad073.029

Research article (journal) | Peer reviewed | Published

Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters.

In: , -.

| Peer reviewed

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ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution de Faria, Flavia W.; Riedel, Nicole C.; Münter, Daniel; Interlandi, Marta; Göbel, Carolin; Altendorf, Lea; Richter, Mathis; Melcher, Viktoria; Thomas, Christian; Roy, Rajanya; Schoof, Melanie; Bedzhov, Ivan; Moreno, Natalia; Graf, Monika; Hotfilder, Marc; Holdhof, Dörthe; Hartmann, Wolfgang; Bruns, Ann-Katrin; Brentrup, Angela; Liesche-Starnecker, Friederike; Maerkl, Bruno; Sandmann, Sarah; Varghese, Julian; Dugas, Martin; Pinto, Pedro H.; Balbach, Sebastian T.;Lu, I-Na; Rossig, Claudia; Soehnlein, Oliver; Canak, Aysegül; Ebinger, Martin; Schuhmann, Martin; Schittenhelm, Jens; Frühwald, Michael F.; Schüller, Ulrich; Albert, Thomas K.; Walter, Carolin; Bruder, Jan M.; Kerl, Kornelius. (2025) In: Nature Communications, 16, 5394. doi:10.1038/s41467-025-60442-9 Research article (journal) \| Peer reviewed \| Published
A Carboxy-terminal Smarcb1 Point Mutation Induces Hydrocephalus Formation and Affects AP-1 and Neuronal Signalling Pathways in Mice Brugmans A.K.; Walter C.; Moreno N.; Göbel C.; Holdhof D.; de Faria F.W.; Hotfilder M.; Jeising D.; Frühwald M.C.; Skryabin B.V.; Rozhdestvensky T.S.; Wachsmuth L.; Faber C.; Dugas M.; Varghese J.; Schüller U.; Albert T.K.; Kerl K. (2023) In: Cellular and Molecular Neurobiology, 43(7), 3511-3526. doi:10.1007/s10571-023-01361-5 Research article (journal) \| Peer reviewed \| Published
The tumor suppressor CREBBP and the oncogene <i>MYCN</i> cooperate to induce malignant brain tumors in mice Schoof, Melanie; Epplen, Gefion Dorothea; Walter, Carolin; Ballast, Annika; Holdhof, Doerthe; Goebel, Carolin; Neyazi, Sina; Varghese, Julian; Albert, Thomas Karl; Kerl, Kornelius; Schueller, Ulrich (2023) In: Oncogenesis, 12(1). doi:10.1038/s41389-023-00481-3 Research article (journal) \| Peer reviewed \| Published
DRUG-CLASS SPECIFIC GENE-BASED MAPK SENSITIVITY SCORES (MSS) PREDICT SENSITIVITY TO MAPK INHIBITORS AND IDENTIFY IMMUNE INFILTRATION AS PUTATIVE TARGET IN PEDIATRIC LOW-GRADE GLIOMAS Sigaud, Romain; Albert, Thomas K.; Hess, Caroline; Hielscher, Thomas; Winkler, Nadine; Walter, Carolin; Muenter, Daniel; Selt, Florian; Usta, Diren; Ecker, Jonas; Brentrup, Angela; Hasselblatt, Martin; Thomas, Christian; Varghese, Julian; Capper, David; Thomale, Ulrich W.; Driever, Pablo Hernaiz; Simon, Michele; Horn, Svea; Herz, Nina Annika; Koch, Arend; Sahm, Felix; Mann, Stefan Hamel; Andrade, Augusto Faria; Jabado, Nada; Schouten-van Meeteren, Antoinette Y. N.; Hoving, Eelco; Brummer, Tilman; van Tilburg, Cornelis M.; Pfister, Stefan M.; Witt, Olaf; Jones, David T. W.; Kerl, Kornelius; Milde, Till (2023) In: Neuro-Oncology, 25. doi:10.1093/neuonc/noad073.212 Research article (journal) \| Peer reviewed \| Published
MOUSE MODELING OF PEDIATRIC MYCN GLIOMA REVEALS INTRATUMORAL HETEROGENEITY INCLUDING NEURONAL AND OLIGODENDROGLIAL LINEAGE SIGNATURES Schoof, Melanie; Godbole, Shweta; Albert, Thomas K.; Termusch, Matthias Dot; Walter, Carolin; Ballast, Annika; Qin, Nan; Olivera, Marlene Baca; Goebel, Carolin; Neyazi, Sina; Holdhof, Dorthe; Kresbach, Catena; Epplen, Gefion Dorothea; Thaden, Vanessa; Blattner-Johnson, Mirjam; Modemann, Franziska; Afflerbach, Ann-Kristin; Eckhardt, Alicia; Muenter, Daniel; Struve, Nina; Jones, David T. W.; Remke, Marc; Neumann, Julia E.; Kerl, Kornelius; Schueller, Ulrich (2023) In: Neuro-Oncology, 25. doi:10.1093/neuonc/noad073.029 Research article (journal) \| Peer reviewed \| Published
Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor In: , -. \| Peer reviewed
Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters. In: , -. \| Peer reviewed
Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells. In: .