The APOL1 variant p.N264K is predicted to block ion flow by occluding a pore at the cell surface.

Höffken V; Console L; Nelde N; Pavenstädt H; Indiveri C; Weide T (2026)

In: Life Science Alliance, 9(5).

Research article (journal)

PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells

Groh, Ann-Christin; Moeller-Kerutt, Annika; Gilhaus, Kevin; Hoeffken, Verena; Nedvetsky, Pavel; Kleimann, Simon; Behrens, Malina; Ghosh, Sujasha; Hansen, Uwe; Krahn, Michael P.; Ebnet, Klaus; Pavenstaedt, Hermann; Ludwig, Alexander; Weide, Thomas (2024)

In: Journal of Cell Science, 137(5).

Research article (journal)

Hypoxia hits APOL1 in the kidney

Schödel J.; Naas S.; Grampp S.; Krüger R.; Lauer V.; Uebel S.; Knaup K.X.; Naas J.; Höffken V.; Weide T.; Schiffer M. (2023)

In: Kidney International, 104.

Research article (journal)

Evolution of Renal-Disease Factor APOL1 Results in Cis and Trans Orientations at the Endoplasmic Reticulum That Both Show Cytotoxic Effects

Müller, Daria; Schmitz, Jürgen; Fischer, Katharina; Granado, Daniel; Groh, Ann-Christin; Krausel, Vanessa; Lüttgenau, Simona Mareike; Amelung, Till Maximilian; Pavenstädt, Hermann (2021)

In: Molecular Biology and Evolution, 38(11).

Research article (journal)

Getting a Notch closer to renal dysfunction: activated Notch suppresses expression of the adaptor protein Disabled-2 in tubular epithelial cells

Schutte-Nutgen, K.; Edeling, M.; Mendl, G.; Krahn, M. P.; Edemir, B.; Weide, T.; Kremerskothen, J.; Michgehl, U.; Pavenstadt, H. (2019)

In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1).

Research article (journal)

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APOL1 plasma membrane pools resist rapid protein degradation. Höffken V; Alvermann L; Niggemeier D; Beul K; Nedvetsky P; Ellinger B; Assenmacher D; Granado D; Pavenstädt H; Weide T (2026) In: Scientific Reports, 16(1). Research article (journal)
The APOL1 variant p.N264K is predicted to block ion flow by occluding a pore at the cell surface. Höffken V; Console L; Nelde N; Pavenstädt H; Indiveri C; Weide T (2026) In: Life Science Alliance, 9(5). Research article (journal)
A Cell Biologist’s View on APOL1: What We Know and What We Still Need to Address Höffken, Verena; Braun, Daniela Anne; Pavenstädt, Hermann; Weide, Thomas (2025) In: Cells, 14. Review article (journal)
PALS1 is a key regulator of the lateral distribution of tight junction proteins in renal epithelial cells Groh, Ann-Christin; Moeller-Kerutt, Annika; Gilhaus, Kevin; Hoeffken, Verena; Nedvetsky, Pavel; Kleimann, Simon; Behrens, Malina; Ghosh, Sujasha; Hansen, Uwe; Krahn, Michael P.; Ebnet, Klaus; Pavenstaedt, Hermann; Ludwig, Alexander; Weide, Thomas (2024) In: Journal of Cell Science, 137(5). Research article (journal)
PALS1-dependent modulations of mRNA profiles in MDCK II cells grown in non-confluent monolayers and three-dimensional cysts Schughart, K; Möller-Kerutt, A; Höffken, V; Nedvetsky, P; Groh, AC; Braun, DA; Pavenstädt, H; Weide, T (2024) In: BMC Genomic Data, 120, 102. Research article (journal)
Hypoxia hits APOL1 in the kidney Schödel J.; Naas S.; Grampp S.; Krüger R.; Lauer V.; Uebel S.; Knaup K.X.; Naas J.; Höffken V.; Weide T.; Schiffer M. (2023) In: Kidney International, 104. Research article (journal)
PATJ inhibits histone deacetylase 7 to control tight junction formation and cell polarity Fiedler, Julia; Moennig, Thomas; Hinrichs, Johanna H.; Weber, Annika; Wagner, Thomas; Hemmer, Tim; Schroeter, Rita; Weide, Thomas; Epting, Daniel; Bergmann, Carsten; Nedvetsky, Pavel; Krahn, Michael P. (2023) In: Cellular and Molecular Life Sciences, 80(11). Research article (journal)
Evolution of Renal-Disease Factor APOL1 Results in Cis and Trans Orientations at the Endoplasmic Reticulum That Both Show Cytotoxic Effects Müller, Daria; Schmitz, Jürgen; Fischer, Katharina; Granado, Daniel; Groh, Ann-Christin; Krausel, Vanessa; Lüttgenau, Simona Mareike; Amelung, Till Maximilian; Pavenstädt, Hermann (2021) In: Molecular Biology and Evolution, 38(11). Research article (journal)
Nephrin Signaling Results in Integrin beta1 Activation Dlugos, C. P.; Picciotto, C.; Lepa, C.; Krakow, M.; Stober, A.; Eddy, M. L.; Weide, T.; Jeibmann, A.; Krahn M. P. ; Van Marck, V.; Klingauf, J. Ricker, A. Wedlich-Soldner, R. Pavenstadt, H. Klambt, C. George, B. (2019) In: Journal of the American Society of Nephrology, 30(6). Research article (journal)
Getting a Notch closer to renal dysfunction: activated Notch suppresses expression of the adaptor protein Disabled-2 in tubular epithelial cells Schutte-Nutgen, K.; Edeling, M.; Mendl, G.; Krahn, M. P.; Edemir, B.; Weide, T.; Kremerskothen, J.; Michgehl, U.; Pavenstadt, H. (2019) In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(1). Research article (journal)