ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution

de Faria, Flavia W.; Riedel, Nicole C.; Münter, Daniel; Interlandi, Marta; Göbel, Carolin; Altendorf, Lea; Richter, Mathis; Melcher, Viktoria; Thomas, Christian; Roy, Rajanya; Schoof, Melanie; Bedzhov, Ivan; Moreno, Natalia; Graf, Monika; Hotfilder, Marc; Holdhof, Dörthe; Hartmann, Wolfgang; Bruns, Ann-Katrin; Brentrup, Angela; Liesche-Starnecker, Friederike; Maerkl, Bruno; Sandmann, Sarah; Varghese, Julian; Dugas, Martin; Pinto, Pedro H.; Balbach, Sebastian T.;Lu, I-Na; Rossig, Claudia; Soehnlein, Oliver; Canak, Aysegül; Ebinger, Martin; Schuhmann, Martin; Schittenhelm, Jens; Frühwald, Michael F.; Schüller, Ulrich; Albert, Thomas K.; Walter, Carolin; Bruder, Jan M.; Kerl, Kornelius. (2025)

In: Nature Communications, 16, 5394.

Research article (journal)

A Carboxy-terminal Smarcb1 Point Mutation Induces Hydrocephalus Formation and Affects AP-1 and Neuronal Signalling Pathways in Mice

Brugmans A.K.; Walter C.; Moreno N.; Göbel C.; Holdhof D.; de Faria F.W.; Hotfilder M.; Jeising D.; Frühwald M.C.; Skryabin B.V.; Rozhdestvensky T.S.; Wachsmuth L.; Faber C.; Dugas M.; Varghese J.; Schüller U.; Albert T.K.; Kerl K. (2023)

In: Cellular and Molecular Neurobiology, 43(7).

Research article (journal)

Defining a Characteristic Gene Expression Set Responsible for Cancer Stem Cell-Like Features in a Sub-Population of Ewing Sarcoma Cells CADO-ES1.

Hotfilder M, Mallela N, Seggewiß J, Dirksen U, Korsching E (2018)

In: International Journal of Molecular Sciences, 19.

Research article (journal)

GD2-SPECIFIC T CELLS EFFICIENTLY TARGET EWING SARCOMA CELLS IN VITRO AND IN VIVO

Kailayangiri S, Altvater B, Meltzer J, Pscherer S, Luecke A, Dierkes C, Leuchte K, Hotfilder M, Dirksen U, Hardes J, Gosheger G, Juergens H, Rossig C (2011)

In: Pediatric Blood and Cancer, 57(5).

Research article (journal)

Cytotoxic T cells transduced with chimeric anti-CD19 receptors prevent engraftment of primary lymphoblastic leukemia in vivo.

Landmeier S, Altvater B, Pscherer S, Meltzer J, Sebire N, Pule M, Vera J, Hotfilder M, Juergens H, Vormoor J, Rossig C (2010)

In: Leukemia, 24(5).

Research article (journal)

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ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution de Faria, Flavia W.; Riedel, Nicole C.; Münter, Daniel; Interlandi, Marta; Göbel, Carolin; Altendorf, Lea; Richter, Mathis; Melcher, Viktoria; Thomas, Christian; Roy, Rajanya; Schoof, Melanie; Bedzhov, Ivan; Moreno, Natalia; Graf, Monika; Hotfilder, Marc; Holdhof, Dörthe; Hartmann, Wolfgang; Bruns, Ann-Katrin; Brentrup, Angela; Liesche-Starnecker, Friederike; Maerkl, Bruno; Sandmann, Sarah; Varghese, Julian; Dugas, Martin; Pinto, Pedro H.; Balbach, Sebastian T.;Lu, I-Na; Rossig, Claudia; Soehnlein, Oliver; Canak, Aysegül; Ebinger, Martin; Schuhmann, Martin; Schittenhelm, Jens; Frühwald, Michael F.; Schüller, Ulrich; Albert, Thomas K.; Walter, Carolin; Bruder, Jan M.; Kerl, Kornelius. (2025) In: Nature Communications, 16, 5394. Research article (journal)
Group-specific cellular metabolism in Medulloblastoma Funke V.L.E.; Walter C.; Melcher V.; Wei L.; Sandmann S.; Hotfilder M.; Varghese J.; Jäger N.; Kool M.; Jones D.T.W.; Pfister S.M.; Milde T.; Mynarek M.; Rutkowski S.; Seggewiss J.; Jeising D.; de Faria F.W.; Marquardt T.; Albert T.K.; Schüller U.; Kerl K. (2023) In: Journal of Translational Medicine, 21(1). Research article (journal)
A Carboxy-terminal Smarcb1 Point Mutation Induces Hydrocephalus Formation and Affects AP-1 and Neuronal Signalling Pathways in Mice Brugmans A.K.; Walter C.; Moreno N.; Göbel C.; Holdhof D.; de Faria F.W.; Hotfilder M.; Jeising D.; Frühwald M.C.; Skryabin B.V.; Rozhdestvensky T.S.; Wachsmuth L.; Faber C.; Dugas M.; Varghese J.; Schüller U.; Albert T.K.; Kerl K. (2023) In: Cellular and Molecular Neurobiology, 43(7). Research article (journal)
Splice variants denote differences between a cancer stem cell side population of EWSR1.ERG.based Ewing sarcoma cells, its main population and EWSR1.FLI.based cells Korsching, E; Matschke, J; Hotfilder, M (2022) In: International Journal of Molecular Medicine, 49(3). Research article (journal)
Defining a Characteristic Gene Expression Set Responsible for Cancer Stem Cell-Like Features in a Sub-Population of Ewing Sarcoma Cells CADO-ES1. Hotfilder M, Mallela N, Seggewiß J, Dirksen U, Korsching E (2018) In: International Journal of Molecular Sciences, 19. Research article (journal)
The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting. Kailayangiri S, Altvater B, Meltzer J, Pscherer S, Luecke A, Dierkes C, Titze U, Leuchte K, Landmeier S, Hotfilder M, Dirksen U, Hardes J, Gosheger G, Juergens H, Rossig C (2012) In: British Journal of Cancer, 106(6). Research article (journal)
GD2-SPECIFIC T CELLS EFFICIENTLY TARGET EWING SARCOMA CELLS IN VITRO AND IN VIVO Kailayangiri S, Altvater B, Meltzer J, Pscherer S, Luecke A, Dierkes C, Leuchte K, Hotfilder M, Dirksen U, Hardes J, Gosheger G, Juergens H, Rossig C (2011) In: Pediatric Blood and Cancer, 57(5). Research article (journal)
Mobilization mechanisms of human primary precursor-B-ALL cells in an in vivo model system by the CXCR4-antagonist AMD3100 and by catecholamines Buss EC, Kalinkovich S, Schajnovitz A, Kollet O, Dar A, Tesio M, Fruehauf S, Hotfilder M, Shultz LD, Ho AD, Lapidot T (2011) In: Onkologie, 34 6. Research article (journal)
Cytotoxic T cells transduced with chimeric anti-CD19 receptors prevent engraftment of primary lymphoblastic leukemia in vivo. Landmeier S, Altvater B, Pscherer S, Meltzer J, Sebire N, Pule M, Vera J, Hotfilder M, Juergens H, Vormoor J, Rossig C (2010) In: Leukemia, 24(5). Research article (journal)
STEAP1-specific T cells for immunotherapy of Ewing sarcoma Kailayangiri S, Altvater B, Landmeier S, Pscherer S, Hotfilder M, Liebsch L, Faber C, Vieth V, Juergens H, Rossig C (2010) In: Klinische Pädiatrie, 222(3). Research article (journal)