The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition.

Dellin, Maurice; Rohrbeck, Ina; Asrani, Purva; Schreiber, Julian A; Ritter, Nadine; Glorius, Frank; Wünsch, Bernhard; Budde, Thomas; Temme, Louisa; Strünker, Timo; Stallmeyer, Birgit; Tüttelmann, Frank; Meuth, Sven G; Spehr, Marc; Matschke, Johann; Steinbicker, Andrea; Gatsogiannis, Christos; Stoll, Raphael; Strutz-Seebohm, Nathalie; Seebohm, Guiscard (2023)
In: Journal of Biological Chemistry, 404(4)
Type of Publication: Research article (journal)

HPLC fluorescence assay for measuring the activity of NAPE-PLD and the action of inhibitors affecting this enzyme.

Lange, Thomas; Depmeier, Tim; Strünker, Timo; Lehr, Matthias (2023)
In: Journal of Pharmaceutical and Biomedical Analysis, 229
Type of Publication: Research article (journal)

Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human.

Schneider, S; Kovacevic, A; Mayer, M; Dicke, AK; Arévalo, L; Koser, SA; Hansen, JN; Young, S; Brenker, C; Kliesch, S; Wachten, D; Kirfel, G; Strünker, T; Tüttelmann, F; Schorle, H (2023)
In: eLife, 12
Type of Publication: Research article (journal)

Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes.

Kierzek, Michelina; Deal, Parker E; Miller, Evan W; Mukherjee, Shatanik; Wachten, Dagmar; Baumann, Arnd; Kaupp, U Benjamin; Strünker, Timo; Brenker, Christoph (2021)
In: eLife, 10
Type of Publication: Research article (journal)

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm

Jeschke, Janice K; Biagioni, Cristina; Schierling, Tobias; Wagner, Isabel Viola; Börgel, Frederik; Schepmann, Dirk; Schüring, Andreas; Kulle, Alexandra E; Holterhus, Paul Martin; von Wolff, Michael; Wünsch, Bernhard; Nordhoff, Verena; Strünker, Timo; Brenker, Christoph (2021)
In: Frontiers in cell and developmental biology, 9
Type of Publication: Research article (journal)

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Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation Young S; Schiffer C; Wagner A; Patz J; Potapenko A; Herrmann L; Nordhoff V; Pock T; Krallmann C; Stallmeyer B; Röpke A; Kierzek M; Biagioni C; Wang T; Haalck L; Deuster D; Hansen JN; Wachten D; Risse B; Behre HM; Schlatt S; Kliesch S; Tüttelmann F; Brenker C; Strünker T (2024) In: Journal of Clinical Investigation, 134(1) Type of Publication: Research article (journal)
The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition. Dellin, Maurice; Rohrbeck, Ina; Asrani, Purva; Schreiber, Julian A; Ritter, Nadine; Glorius, Frank; Wünsch, Bernhard; Budde, Thomas; Temme, Louisa; Strünker, Timo; Stallmeyer, Birgit; Tüttelmann, Frank; Meuth, Sven G; Spehr, Marc; Matschke, Johann; Steinbicker, Andrea; Gatsogiannis, Christos; Stoll, Raphael; Strutz-Seebohm, Nathalie; Seebohm, Guiscard (2023) In: Journal of Biological Chemistry, 404(4) Type of Publication: Research article (journal)
Pathogenic gene variants in CCDC39, CCDC40, RSPH1, RSPH9, HYDIN, and SPEF2 cause defects of sperm flagella composition and male infertility. Aprea, I; Wilken, A; Krallmann, C; Nöthe-Menchen, T; Olbrich, H; Loges, NT; Dougherty, GW; Bracht, D; Brenker, C; Kliesch, S; Strünker, T; Tüttelmann, F; Raidt, J; Omran, H (2023) In: Frontiers in Genetics, 14 Type of Publication: Research article (journal)
HPLC fluorescence assay for measuring the activity of NAPE-PLD and the action of inhibitors affecting this enzyme. Lange, Thomas; Depmeier, Tim; Strünker, Timo; Lehr, Matthias (2023) In: Journal of Pharmaceutical and Biomedical Analysis, 229 Type of Publication: Research article (journal)
Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives Ritter N; Disse P; Aymanns I; Mücher L; Schreiber JA; Brenker C; Strünker T; Schepmann D; Budde T; Strutz-Seebohm N; Ametamey SM; Wünsch B; Seebohm G (2023) In: Molecular Neurobiology, 60(12) Type of Publication: Research article (journal)
Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human. Schneider, S; Kovacevic, A; Mayer, M; Dicke, AK; Arévalo, L; Koser, SA; Hansen, JN; Young, S; Brenker, C; Kliesch, S; Wachten, D; Kirfel, G; Strünker, T; Tüttelmann, F; Schorle, H (2023) In: eLife, 12 Type of Publication: Research article (journal)
The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm Rahban, Rita; Rehfeld, Anders; Schiffer, Christian; Brenker, Christoph; Egeberg Palme, Dorte Luise; Wand, Tao; Lorenz, Johannes; Almstrup, Kristian; Skakkebaek, Niels E; Strünker, Timo; Nef, Serge (2021) In: Human Reproduction, 36(10) Type of Publication: Research article (journal)
Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes. Kierzek, Michelina; Deal, Parker E; Miller, Evan W; Mukherjee, Shatanik; Wachten, Dagmar; Baumann, Arnd; Kaupp, U Benjamin; Strünker, Timo; Brenker, Christoph (2021) In: eLife, 10 Type of Publication: Research article (journal)
Motility of efferent duct cilia aids passage of sperm cells through the male reproductive system. Aprea, Isabella; Nöthe-Menchen, Tabea; Dougherty, Gerard W; Raidt, Johanna; Loges, Niki T; Kaiser, Thomas; Wallmeier, Julia; Ulbrich, Heike; Strünker, Timo; Kliesch, Sabine; Pennekamp, Petra; Omran, Heymut (2021) In: Molecular Human Reproduction, 27(3) Type of Publication: Research article (journal)
The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm Jeschke, Janice K; Biagioni, Cristina; Schierling, Tobias; Wagner, Isabel Viola; Börgel, Frederik; Schepmann, Dirk; Schüring, Andreas; Kulle, Alexandra E; Holterhus, Paul Martin; von Wolff, Michael; Wünsch, Bernhard; Nordhoff, Verena; Strünker, Timo; Brenker, Christoph (2021) In: Frontiers in cell and developmental biology, 9 Type of Publication: Research article (journal)