Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases

Herrmann, Leonie; Brenker, Christoph; Mittermair, Teresa; Bojovic, Vesna; Münchow, Jens; Zhu, W. Felix; Trugge, Carla; Fußhöller, David; Jikeli, Jan; Temme, Louisa; Kaupp, U. Benjamin; Strünker, Strünker (2025)

In: British Journal of Pharmacology, 182(12).

Research article (journal)

Pathogenic gene variants in CCDC39, CCDC40, RSPH1, RSPH9, HYDIN, and SPEF2 cause defects of sperm flagella composition and male infertility.

Aprea, I; Wilken, A; Krallmann, C; Nöthe-Menchen, T; Olbrich, H; Loges, NT; Dougherty, GW; Bracht, D; Brenker, C; Kliesch, S; Strünker, T; Tüttelmann, F; Raidt, J; Omran, H (2023)

In: Frontiers in Genetics, 14.

Research article (journal)

The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm

Rahban, Rita; Rehfeld, Anders; Schiffer, Christian; Brenker, Christoph; Egeberg Palme, Dorte Luise; Wand, Tao; Lorenz, Johannes; Almstrup, Kristian; Skakkebaek, Niels E; Strünker, Timo; Nef, Serge (2021)

In: Human Reproduction, 36(10).

Research article (journal)

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm

Jeschke, Janice K; Biagioni, Cristina; Schierling, Tobias; Wagner, Isabel Viola; Börgel, Frederik; Schepmann, Dirk; Schüring, Andreas; Kulle, Alexandra E; Holterhus, Paul Martin; von Wolff, Michael; Wünsch, Bernhard; Nordhoff, Verena; Strünker, Timo; Brenker, Christoph (2021)

In: Frontiers in cell and developmental biology, 9.

Research article (journal)

The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA.

Wang, Tao; Young, Samuel; Krenz, Henrike; Tüttelmann, Frank; Röpke, Albrecht; Krallmann, Claudia; Kliesch, Sabine; Zeng, Xu-Hui; Brenker, Christoph; Strünker, Timo (2020)

In: Journal of Biological Chemistry, 295(38).

Research article (journal)

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Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases Herrmann, Leonie; Brenker, Christoph; Mittermair, Teresa; Bojovic, Vesna; Münchow, Jens; Zhu, W. Felix; Trugge, Carla; Fußhöller, David; Jikeli, Jan; Temme, Louisa; Kaupp, U. Benjamin; Strünker, Strünker (2025) In: British Journal of Pharmacology, 182(12). Research article (journal)
Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation Young S; Schiffer C; Wagner A; Patz J; Potapenko A; Herrmann L; Nordhoff V; Pock T; Krallmann C; Stallmeyer B; Röpke A; Kierzek M; Biagioni C; Wang T; Haalck L; Deuster D; Hansen JN; Wachten D; Risse B; Behre HM; Schlatt S; Kliesch S; Tüttelmann F; Brenker C; Strünker T (2024) In: Journal of Clinical Investigation, 134(1). Research article (journal)
Pathogenic gene variants in CCDC39, CCDC40, RSPH1, RSPH9, HYDIN, and SPEF2 cause defects of sperm flagella composition and male infertility. Aprea, I; Wilken, A; Krallmann, C; Nöthe-Menchen, T; Olbrich, H; Loges, NT; Dougherty, GW; Bracht, D; Brenker, C; Kliesch, S; Strünker, T; Tüttelmann, F; Raidt, J; Omran, H (2023) In: Frontiers in Genetics, 14. Research article (journal)
Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives Ritter N; Disse P; Aymanns I; Mücher L; Schreiber JA; Brenker C; Strünker T; Schepmann D; Budde T; Strutz-Seebohm N; Ametamey SM; Wünsch B; Seebohm G (2023) In: Molecular Neurobiology, 60(12). Research article (journal)
The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm Rahban, Rita; Rehfeld, Anders; Schiffer, Christian; Brenker, Christoph; Egeberg Palme, Dorte Luise; Wand, Tao; Lorenz, Johannes; Almstrup, Kristian; Skakkebaek, Niels E; Strünker, Timo; Nef, Serge (2021) In: Human Reproduction, 36(10). Research article (journal)
Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes. Kierzek, Michelina; Deal, Parker E; Miller, Evan W; Mukherjee, Shatanik; Wachten, Dagmar; Baumann, Arnd; Kaupp, U Benjamin; Strünker, Timo; Brenker, Christoph (2021) In: eLife, 10. Research article (journal)
The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm Jeschke, Janice K; Biagioni, Cristina; Schierling, Tobias; Wagner, Isabel Viola; Börgel, Frederik; Schepmann, Dirk; Schüring, Andreas; Kulle, Alexandra E; Holterhus, Paul Martin; von Wolff, Michael; Wünsch, Bernhard; Nordhoff, Verena; Strünker, Timo; Brenker, Christoph (2021) In: Frontiers in cell and developmental biology, 9. Research article (journal)
Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling Schiffer Christian, Rieger Steffen, Brenker Christoph, Young Samuel, Hamzeh Hussein, Wachten Dagmar, Tüttelmann Frank, Röpke Albrecht, Kaupp Benjamin U, Wang Tao, Wagner Alice, Krallmann Claudia, Kliesch Sabine, Fallnich Carsten, Strünker Timo (2020) In: The EMBO Journal, 2020(e102363). Research article (journal)
The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA. Wang, Tao; Young, Samuel; Krenz, Henrike; Tüttelmann, Frank; Röpke, Albrecht; Krallmann, Claudia; Kliesch, Sabine; Zeng, Xu-Hui; Brenker, Christoph; Strünker, Timo (2020) In: Journal of Biological Chemistry, 295(38). Research article (journal)
Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling. Schiffer, Christian; Rieger, Steffen; Brenker, Christoph; Young, Samuel; Hamzeh, Hussein; Wachten, Dagmar; Tüttelmann, Frank; Röpke, Albrecht; Kaupp, U Benjamin; Wang, Tao; Wagner, Alice; Krallmann, Claudia; Kliesch, Sabine; Fallnich, Carsten; Strünker, Timo (2020) In: The EMBO Journal, 39(4). Research article (journal)