Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation

Young S; Schiffer C; Wagner A; Patz J; Potapenko A; Herrmann L; Nordhoff V; Pock T; Krallmann C; Stallmeyer B; Röpke A; Kierzek M; Biagioni C; Wang T; Haalck L; Deuster D; Hansen JN; Wachten D; Risse B; Behre HM; Schlatt S; Kliesch S; Tüttelmann F; Brenker C; Strünker T (2024)
In: Journal of Clinical Investigation, 134(1)
Type of Publication: Research article (journal)

Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives

Ritter N; Disse P; Aymanns I; Mücher L; Schreiber JA; Brenker C; Strünker T; Schepmann D; Budde T; Strutz-Seebohm N; Ametamey SM; Wünsch B; Seebohm G (2023)
In: Molecular Neurobiology, 60(12)
Type of Publication: Research article (journal)

Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes.

Kierzek, Michelina; Deal, Parker E; Miller, Evan W; Mukherjee, Shatanik; Wachten, Dagmar; Baumann, Arnd; Kaupp, U Benjamin; Strünker, Timo; Brenker, Christoph (2021)
In: eLife, 10
Type of Publication: Research article (journal)

Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling

Schiffer Christian, Rieger Steffen, Brenker Christoph, Young Samuel, Hamzeh Hussein, Wachten Dagmar, Tüttelmann Frank, Röpke Albrecht, Kaupp Benjamin U, Wang Tao, Wagner Alice, Krallmann Claudia, Kliesch Sabine, Fallnich Carsten, Strünker Timo (2020)
In: EMBO Journal, 2020(e102363)
Type of Publication: Research article (journal)

Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling.

Schiffer, Christian; Rieger, Steffen; Brenker, Christoph; Young, Samuel; Hamzeh, Hussein; Wachten, Dagmar; Tüttelmann, Frank; Röpke, Albrecht; Kaupp, U Benjamin; Wang, Tao; Wagner, Alice; Krallmann, Claudia; Kliesch, Sabine; Fallnich, Carsten; Strünker, Timo (2020)
In: EMBO Journal, 39(4)
Type of Publication: Research article (journal)

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Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation Young S; Schiffer C; Wagner A; Patz J; Potapenko A; Herrmann L; Nordhoff V; Pock T; Krallmann C; Stallmeyer B; Röpke A; Kierzek M; Biagioni C; Wang T; Haalck L; Deuster D; Hansen JN; Wachten D; Risse B; Behre HM; Schlatt S; Kliesch S; Tüttelmann F; Brenker C; Strünker T (2024) In: Journal of Clinical Investigation, 134(1) Type of Publication: Research article (journal)
Pathogenic gene variants in CCDC39, CCDC40, RSPH1, RSPH9, HYDIN, and SPEF2 cause defects of sperm flagella composition and male infertility. Aprea, I; Wilken, A; Krallmann, C; Nöthe-Menchen, T; Olbrich, H; Loges, NT; Dougherty, GW; Bracht, D; Brenker, C; Kliesch, S; Strünker, T; Tüttelmann, F; Raidt, J; Omran, H (2023) In: Frontiers in Genetics, 14 Type of Publication: Research article (journal)
Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives Ritter N; Disse P; Aymanns I; Mücher L; Schreiber JA; Brenker C; Strünker T; Schepmann D; Budde T; Strutz-Seebohm N; Ametamey SM; Wünsch B; Seebohm G (2023) In: Molecular Neurobiology, 60(12) Type of Publication: Research article (journal)
The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm Rahban, Rita; Rehfeld, Anders; Schiffer, Christian; Brenker, Christoph; Egeberg Palme, Dorte Luise; Wand, Tao; Lorenz, Johannes; Almstrup, Kristian; Skakkebaek, Niels E; Strünker, Timo; Nef, Serge (2021) In: Human Reproduction, 36(10) Type of Publication: Research article (journal)
Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes. Kierzek, Michelina; Deal, Parker E; Miller, Evan W; Mukherjee, Shatanik; Wachten, Dagmar; Baumann, Arnd; Kaupp, U Benjamin; Strünker, Timo; Brenker, Christoph (2021) In: eLife, 10 Type of Publication: Research article (journal)
The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm Jeschke, Janice K; Biagioni, Cristina; Schierling, Tobias; Wagner, Isabel Viola; Börgel, Frederik; Schepmann, Dirk; Schüring, Andreas; Kulle, Alexandra E; Holterhus, Paul Martin; von Wolff, Michael; Wünsch, Bernhard; Nordhoff, Verena; Strünker, Timo; Brenker, Christoph (2021) In: Frontiers in cell and developmental biology, 9 Type of Publication: Research article (journal)
Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling Schiffer Christian, Rieger Steffen, Brenker Christoph, Young Samuel, Hamzeh Hussein, Wachten Dagmar, Tüttelmann Frank, Röpke Albrecht, Kaupp Benjamin U, Wang Tao, Wagner Alice, Krallmann Claudia, Kliesch Sabine, Fallnich Carsten, Strünker Timo (2020) In: EMBO Journal, 2020(e102363) Type of Publication: Research article (journal)
The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA. Wang, Tao; Young, Samuel; Krenz, Henrike; Tüttelmann, Frank; Röpke, Albrecht; Krallmann, Claudia; Kliesch, Sabine; Zeng, Xu-Hui; Brenker, Christoph; Strünker, Timo (2020) In: Journal of Biological Chemistry, 295(38) Type of Publication: Research article (journal)
Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca2+ signaling. Schiffer, Christian; Rieger, Steffen; Brenker, Christoph; Young, Samuel; Hamzeh, Hussein; Wachten, Dagmar; Tüttelmann, Frank; Röpke, Albrecht; Kaupp, U Benjamin; Wang, Tao; Wagner, Alice; Krallmann, Claudia; Kliesch, Sabine; Fallnich, Carsten; Strünker, Timo (2020) In: EMBO Journal, 39(4) Type of Publication: Research article (journal)
The Ca21 channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA Wang, Tao; Young, Samuel; Krenz, Henrike; Tüttelmann, Frank; Röpke, Albrecht; Krallmann, Claudia; Kliesch, Sabine; Zeng, Xu-Hui; Brenker, Christoph; Strünker, Timo (2020) In: Journal of Biological Chemistry, 295(38) Type of Publication: Research article (journal)