[18F]Fluspidine – a PET tracer for imaging of 1 receptors in the central nervous system

F. A. Ludwig, E. Laurini, J. Schmidt, S. Pricl, W. Deuther-Conrad, B. Wünsch (2024)
In: Pharmaceuticals, 17
Type of Publication: Research article (journal)

A novel NMDA Receptor-Test Model based on hiPSC-derived neural cells.

P. Disse, I. Aymanns, N. Ritter, S. Peischard, L. Korn, H. Wiendl, M. Pawlowski, S. Kovac, S. G. Meuth, T. Budde, N. Strutz-Seebohm, B. Wünsch, G. Seebohm, Biol. Chem. 2022, submitted. (2023)
In: Biological Chemistry, 404(4)
Type of Publication: Research article (journal)

In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs

E. Bechthold, L. Grey, E. Diamant, J. Schmidt, R. Steigerwald, F. Zhao, K. B. Hansen, L. Bunch, R. P. Clausen, B. Wünsch (2023)
In: Biological Chemistry, 404(4)
Type of Publication: Research article (journal)

The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition.

M. Dellin, I. Rohrbeck, P. Asrani, J. A. Schreiber, N. Ritter, F. Glorius, B. Wünsch, T. Budde, L. Temme, T. Strünker, B. Stallmeyer, F. Tüttelmann, S. G. Meuth, M. Spehr, J. Matschke, A. Steinbicker, R. Stoll, N. Strutz-Seebohm, G. Seebohm (2023)
In: Biological Chemistry, 404(4)
Type of Publication: Research article (journal)

Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation.

C. B. Schroeter, C. Nelke, M. Schewe, L. Spohler, A. M. Herrmann, T. Müntefering, N. Huntemann, M. Kuzikov, P. Gribbon, S. Albrecht, S. Bock, P. Hundehege, L. C. Neelsen, T. Baukrowitz, G. Seebohm, B. Wünsch, S. Bittner, T. Ruck, T. Budde, S. G. Meuth (2023)
In: Biological Chemistry, 404(4)
Type of Publication: Research article (journal)

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[18F]Fluspidine – a PET tracer for imaging of 1 receptors in the central nervous system F. A. Ludwig, E. Laurini, J. Schmidt, S. Pricl, W. Deuther-Conrad, B. Wünsch (2024) In: Pharmaceuticals, 17 Type of Publication: Research article (journal)
Late-stage diversification of pyrazoles as antileishmanial agents. T. Winge, B. Perry, A. Matheeussen, G. Caljon, B. Wünsch (2024) In: ChemMedChem, 2024 Type of Publication: Research article (journal)
A novel NMDA Receptor-Test Model based on hiPSC-derived neural cells. P. Disse, I. Aymanns, N. Ritter, S. Peischard, L. Korn, H. Wiendl, M. Pawlowski, S. Kovac, S. G. Meuth, T. Budde, N. Strutz-Seebohm, B. Wünsch, G. Seebohm, Biol. Chem. 2022, submitted. (2023) In: Biological Chemistry, 404(4) Type of Publication: Research article (journal)
Chemical, pharmacodynamic and pharmacokinetic characterization of the GluN2B receptor antagonist 3-(4-phenylbutyl),2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol – starting point… M. Korff, R. Steigerwald, E. Bechthold, D. Schepmann, J. A. Schreiber, S. G. Meuth, G. Seebohm, B. Wünsch (2023) In: Biological Chemistry, 404(4) Type of Publication: Research article (journal)
In vitro ADME characterization of a very potent 3-acylamino-2-aminopropionic acid-derived GluN2C-NMDA receptor agonist and its ester prodrugs E. Bechthold, L. Grey, E. Diamant, J. Schmidt, R. Steigerwald, F. Zhao, K. B. Hansen, L. Bunch, R. P. Clausen, B. Wünsch (2023) In: Biological Chemistry, 404(4) Type of Publication: Research article (journal)
Molecular mechanism of biased signaling at the kappa opioid receptor. A. El Daibani, J. M. Paggi, K. Kim, Y. Laloudakis, P. Popov, S. M. Bernhard, R. H. J. Olsen, J. Diberto, F. I. Carroll, V. Katritch, B. Wünsch, R. O. Dror, T. Che (2023) In: Nature Communications, 14 Type of Publication: Research article (journal)
The second PI(3,5)P2 binding site in the S0 helix of KCNQ1 stabilizes PIP2-at the primary PI1 site with potential consequences on intermediate-to-open state transition. M. Dellin, I. Rohrbeck, P. Asrani, J. A. Schreiber, N. Ritter, F. Glorius, B. Wünsch, T. Budde, L. Temme, T. Strünker, B. Stallmeyer, F. Tüttelmann, S. G. Meuth, M. Spehr, J. Matschke, A. Steinbicker, R. Stoll, N. Strutz-Seebohm, G. Seebohm (2023) In: Biological Chemistry, 404(4) Type of Publication: Research article (journal)
Synthesis and functional characterization of novel RU1968-derived CatSper inhibitors with reduced stereochemical complexity. T. Schierling, B. Tosi, C. Eisenhardt, S. Reining, C. Daniliuc, C. Brenker, T. Strünker, B. Wünsch (2023) In: ACS Pharmacology and Translational Science, 6(1) Type of Publication: Research article (journal)
Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation. C. B. Schroeter, C. Nelke, M. Schewe, L. Spohler, A. M. Herrmann, T. Müntefering, N. Huntemann, M. Kuzikov, P. Gribbon, S. Albrecht, S. Bock, P. Hundehege, L. C. Neelsen, T. Baukrowitz, G. Seebohm, B. Wünsch, S. Bittner, T. Ruck, T. Budde, S. G. Meuth (2023) In: Biological Chemistry, 404(4) Type of Publication: Research article (journal)
Pharmacological Potential of 3-Benzazepines in NMDAR-Linked Pathophysiological Processes Ritter, Nadine; Disse, Paul; Wünsch, Bernhard; Seebohm, Guiscard; Strutz-Seebohm, Nathalie (2023) In: Biomedicines, 11(5) Type of Publication: Research article (journal)