Engineered SAM synthetases for enzymatic generation of AdoMet analogs with photocaging groups and reversible DNA modification in cascade reactions

Michailidou F, Klöcker N, Cornelissen NV, Singh RK, Peters A, Ovcharenko A, Kümmel D, Rentmeister A (2021)

In: Angewandte Chemie International Edition, 60(1).

Research article (journal)

TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation

Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, {Linard Matos} AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D (2021)

In: Molecular Cell, 2021.

Research article (journal)

Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer.

Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan C, Singh RK, Apken LH, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP, Askan G, Grbovic-Huezo O, Ogrodowski P, Bermeo J, Saglimbeni J, Cruz CD, Ho Y, Lawrence SA, Melchor JP, Goda GA, Bai K, Pastore A, Hogg SJ, Raghavan S, Bailey P, Chang DK, Biankin A, Shroyer KR, Wolpin BM, Aguirre AJ, Ventura A, Taylor B, Der CJ, Dominguez D, Kümmel D, Oeckinghaus A, Lowe SW, Bradley RK, Abdel-Wahab O, Leach SD (2020)

In: Cancer cell, 38(2).

Research article (journal)

Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction

Lynagh T, Kiontke S, Meyhoff-Madsen M, Gless BH, Johannesen J, Kattelmann S, Christiansen A, Dufva M, Laustsen AH, Devkota K, Olsen CA, Kümmel D, Pless SA, Lohse B (2020)

In: Journal of Medicinal Chemistry, 63(22).

Research article (journal)

Structure of membrane tethers and their role in fusion

Ungermann C, Kümmel D (2019)

In: ((Bitte Journal prüfen)), 20(7).

Research article (journal)

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Chemo-enzymatic production of base-modified ATP analogues for polyadenylation of RNA Mitton-Fry, Rachel M.; Eschenbach, Jannik; Schepers, Helena; Rasche, René; Erguven, Mehmet; Kümmel, Daniel; Rentmeister, Andrea; Cornelissen, Nicolas V. (2024) In: Chemical science, 15(32). Research article (journal)
Engineered SAM synthetases for enzymatic generation of AdoMet analogs with photocaging groups and reversible DNA modification in cascade reactions Michailidou F, Klöcker N, Cornelissen NV, Singh RK, Peters A, Ovcharenko A, Kümmel D, Rentmeister A (2021) In: Angewandte Chemie International Edition, 60(1). Research article (journal)
Biochemical and Structural Characterization of an Unusual and Naturally Split Class 3 Intein Hoffmann S, Terhorst TME, Singh RK, Kümmel D, Pietrokovski S, Mootz HD (2021) In: ((Bitte Journal prüfen)), 22(2). Research article (journal)
TSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation Fitzian K, Brückner A, Brohée L, Zech R, Antoni C, Kiontke S, Gasper R, {Linard Matos} AL, Beel S, Wilhelm S, Gerke V, Ungermann C, Nellist M, Raunser S, Demetriades C, Oeckinghaus A, Kümmel D (2021) In: Molecular Cell, 2021. Research article (journal)
Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations. Hansmann P, Brückner A, Kiontke S, Berkenfeld B, Seebohm G, Brouillard P, Vikkula M, Jansen FE, Nellist M, Oeckinghaus A, Kümmel D (2020) In: Structure, 28(8). Research article (journal)
Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer. Escobar-Hoyos LF, Penson A, Kannan R, Cho H, Pan C, Singh RK, Apken LH, Hobbs GA, Luo R, Lecomte N, Babu S, Pan FC, Alonso-Curbelo D, Morris JP, Askan G, Grbovic-Huezo O, Ogrodowski P, Bermeo J, Saglimbeni J, Cruz CD, Ho Y, Lawrence SA, Melchor JP, Goda GA, Bai K, Pastore A, Hogg SJ, Raghavan S, Bailey P, Chang DK, Biankin A, Shroyer KR, Wolpin BM, Aguirre AJ, Ventura A, Taylor B, Der CJ, Dominguez D, Kümmel D, Oeckinghaus A, Lowe SW, Bradley RK, Abdel-Wahab O, Leach SD (2020) In: Cancer cell, 38(2). Research article (journal)
Comparison of the functional and structural characteristics of rare TSC2 variants with clinical and genetic findings {Dufner Almeida} LG, Nanhoe S, Zonta A, Hosseinzadeh M, Kom-Gortat R, Elfferich P, Schaaf G, Kenter A, Kümmel D, Migone N, Povey S, Ekong R, Nellist M (2020) In: Human Mutation, 41(4). Research article (journal)
Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction Lynagh T, Kiontke S, Meyhoff-Madsen M, Gless BH, Johannesen J, Kattelmann S, Christiansen A, Dufva M, Laustsen AH, Devkota K, Olsen CA, Kümmel D, Pless SA, Lohse B (2020) In: Journal of Medicinal Chemistry, 63(22). Research article (journal)
A conserved and regulated mechanism drives endosomal Rab transition Langemeyer L, Borchers A, Herrmann E, Füllbrunn N, Han Y, Perz A, Auffarth K, Kümmel D, Ungermann C (2020) In: eLife, 9. Research article (journal)
Structure of membrane tethers and their role in fusion Ungermann C, Kümmel D (2019) In: ((Bitte Journal prüfen)), 20(7). Research article (journal)